ID Capan-2 AC CVCL_0026 SY CaPan-2; CAPAN-2; Capan 2; CAPAN 2; Capan2; CAPAN2 DR BTO; BTO_0002745 DR CLO; CLO_0002198 DR EFO; EFO_0002154 DR MCCL; MCC:0000127 DR CLDB; cl642 DR CLDB; cl643 DR CLDB; cl644 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; HTB-80 DR BCRJ; 0060 DR BioSample; SAMN03472025 DR BioSample; SAMN03473387 DR BioSample; SAMN10988212 DR cancercelllines; CVCL_0026 DR CancerTools; 161908 DR Cell_Model_Passport; SIDM00943 DR CGH-DB; 163-1 DR CGH-DB; 9270-4 DR ChEMBL-Cells; CHEMBL3308720 DR ChEMBL-Targets; CHEMBL1075417 DR CLS; 300144 DR Cosmic; 730527 DR Cosmic; 736271 DR Cosmic; 755303 DR Cosmic; 808163 DR Cosmic; 868246 DR Cosmic; 910915 DR Cosmic; 913303 DR Cosmic; 922256 DR Cosmic; 923167 DR Cosmic; 932517 DR Cosmic; 932987 DR Cosmic; 933522 DR Cosmic; 934554 DR Cosmic; 947396 DR Cosmic; 948727 DR Cosmic; 949232 DR Cosmic; 1006366 DR Cosmic; 1108339 DR Cosmic; 1299297 DR Cosmic; 1320463 DR Cosmic; 1366277 DR Cosmic; 1571775 DR Cosmic; 1995363 DR Cosmic; 2009527 DR Cosmic; 2046535 DR Cosmic; 2434087 DR Cosmic; 2668288 DR Cosmic-CLP; 910915 DR DepMap; ACH-000107 DR DSMZ; ACC-245 DR DSMZCellDive; ACC-245 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 910915 DR GEO; GSM206453 DR GEO; GSM621896 DR GEO; GSM784710 DR GEO; GSM886921 DR GEO; GSM887987 DR GEO; GSM1024399 DR GEO; GSM1374440 DR GEO; GSM1669664 DR GEO; GSM7701427 DR GEO; GSM7701428 DR IARC_TP53; 313 DR IARC_TP53; 21042 DR IARC_TP53; 30199 DR IGRhCellID; Capan2 DR IZSLER; BS TCL 10 DR KCLB; 30080 DR LiGeA; CCLE_178 DR LINCS_LDP; LCL-1733 DR Lonza; 1464 DR MetaboLights; MTBLS812 DR PharmacoDB; Capan2_185_2019 DR PRIDE; PXD003198 DR PRIDE; PXD030304 DR Progenetix; CVCL_0026 DR PubChem_Cell_line; CVCL_0026 DR SKY/M-FISH/CGH; 1993 DR Wikidata; Q54808591 RX DOI=10.22029/jlupub-12385; RX DOI=10.4172/jpb.1000057; RX PubMed=1630814; RX PubMed=1764370; RX PubMed=3019537; RX PubMed=3518877; RX PubMed=6582512; RX PubMed=6935474; RX PubMed=7459858; RX PubMed=7809022; RX PubMed=7961102; RX PubMed=7972006; RX PubMed=8026879; RX PubMed=8194712; RX PubMed=8286197; RX PubMed=8426738; RX PubMed=10027410; RX PubMed=11169957; RX PubMed=11169959; RX PubMed=11668190; RX PubMed=12692724; RX PubMed=12800145; RX PubMed=14695172; RX PubMed=15126341; RX PubMed=15367885; RX PubMed=15688027; RX PubMed=15770730; RX PubMed=16957166; RX PubMed=18298655; RX PubMed=18380791; RX PubMed=20037478; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=20418756; RX PubMed=22460905; RX PubMed=22585861; RX PubMed=24700732; RX PubMed=25167228; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26216984; RX PubMed=26589293; RX PubMed=27259358; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=31037374; RX PubMed=31068700; RX PubMed=35839778; WW Info; HPA; -; https://www.proteinatlas.org/learn/cellines WW Info; Pawefish; -; https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/capan-2.html WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-178.html WW Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/capan-2-human-pancreatic-adenocarcinoma-cell-line CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: Human Protein Atlas, Cell Atlas panel. CC Part of: NCI RAS program mutant KRAS cell line panel. CC From: Memorial Sloan Kettering Cancer Center; New York; USA. CC Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK2000-049. CC Population: Caucasian. CC Doubling time: 96 hours (PubMed=3019537); 45-60 hours (CLS=300144); ~50-70 hours (DSMZ=ACC-245). CC HLA typing: A*29:02,29:02; B*44:03,44:03; C*16:01,16:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Thr18_Ala19dup (c.52_57dupACGGCC); ClinVar=VCV000579466; Zygosity=Homozygous (PubMed=7972006; DepMap=ACH-000107). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous (PubMed=7961102; PubMed=8026879; PubMed=8426738; PubMed=11169959; PubMed=15367885; Cosmic-CLP=910915; DepMap=ACH-000107). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr125Thr (c.375G>T); ClinVar=VCV000237948; Zygosity=Homozygous; Note=Impairs TP53 splicing dramatically (PubMed=7961102; PubMed=8026879; PubMed=24700732; DepMap=ACH-000107). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Metabolomics. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics. CC Omics: Proteomics; 2DE-MS. CC Omics: Proteomics; Expression; Large antibody panel staining analysis. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.28%; Native American=0.63%; East Asian, North=0.28%; East Asian, South=0%; South Asian=0.34%; European, North=62.52%; European, South=35.95% (PubMed=30894373). CC Caution: TP53 mutation indicated incorrectly as being at c.818G>A in PubMed=1630814. CC Misspelling: CANPAN-2; Cosmic=2434087. CC Derived from site: In situ; Pancreas; UBERON=UBERON_0001264. ST Source(s): ATCC=HTB-80; CLS=300144; Cosmic-CLP=910915; DSMZ=ACC-245; KCLB=30080; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 11,12 ST D13S317: 11,12 ST D16S539: 9,13 ST D18S51: 13 ST D19S433: 13,15 ST D21S11: 31 ST D2S1338: 19,25 ST D3S1358: 17,18 ST D5S818: 11,12 ST D7S820: 9,11 ST D8S1179: 12,13 ST FGA: 21,24 ST Penta D: 13,15 ST Penta E: 11 ST TH01: 9.3 ST TPOX: 8 ST vWA: 16,17 (DSMZ=ACC-245) ST vWA: 17 (ATCC=HTB-80; CLS=300144; Cosmic-CLP=910915; PubMed=25877200) ST vWA: 17,19 (KCLB=30080) DI NCIt; C9120; Pancreatic ductal adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 56Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 49 // RX PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C; RA Sirivatanauksorn, Vorapan RA Sirivatanauksorn, Yongyut RA Gorman, Patricia A. RA Davidson, Jeffrey M. RA Sheer, Denise RA Moore, Patrick S. RA Scarpa, Aldo RA Edwards, Paul A.W. RA Lemoine, Nicholas Robert RT "Non-random chromosomal rearrangements in pancreatic cancer cell lines RT identified by spectral karyotyping."; RL Int. J. Cancer 91:350-358(2001). // RX PubMed=24700732; DOI=10.1002/humu.22556; PMCID=PMC4451114; RA Leroy, Bernard RA Girard, Luc RA Hollestelle, Antoinette RA Minna, John D. RA Gazdar, Adi F. RA Soussi, Thierry RT "Analysis of TP53 mutation status in human cancer cell lines: a RT reassessment."; RL Hum. Mutat. 35:756-765(2014). // RX PubMed=11668190; DOI=10.1177/002215540104901105; RA Quentmeier, Hilmar RA Osborn, Mary RA Reinhardt, Julia RA Zaborski, Margarete RA Drexler, Hans Gunther RT "Immunocytochemical analysis of cell lines derived from solid RT tumors."; RL J. Histochem. Cytochem. 49:1369-1378(2001). // RX DOI=10.22029/jlupub-12385; RA Oberlin, Laura RT "Treatment of pancreatic carcinoma cell lines in vitro and vivo with a RT monoclonal antibody against the transferrin receptor."; RL Thesis VMD (2009); Justus-Liebig-Universitat Giessen; Giessen; Germany. // RX PubMed=12692724; DOI=10.1007/s00428-003-0784-4; RA Sipos, Bence RA Moser, Simone RA Kalthoff, Holger RA Torok, Virag RA Lohr, Johannes-Matthias RA Kloppel, Gunter RT "A comprehensive characterization of pancreatic ductal carcinoma cell RT lines: towards the establishment of an in vitro research platform."; RL Virchows Arch. 442:444-452(2003). // RX PubMed=12800145; DOI=10.1002/gcc.10218; RA Adelaide, Jose RA Huang, Huai-En RA Murati, Anne RA Alsop, Amber E. RA Orsetti, Beatrice RA Mozziconacci, Marie-Joelle RA Popovici, Cornel RA Ginestier, Christophe RA Letessier, Anne RA Basset, Celine RA Courtay-Cahen, Celine RA Jacquemier, Jocelyne RA Theillet, Charles RA Birnbaum, Daniel RA Edwards, Paul A.W. RA Chaffanet, Max RT "A recurrent chromosome translocation breakpoint in breast and RT pancreatic cancer cell lines targets the neuregulin/NRG1 gene."; RL Genes Chromosomes Cancer 37:333-345(2003). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=11169957; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1014>3.0.CO;2-U; RA Wallrapp, Christine RA Hahnel, Susanne RA Boeck, Wolfgang RA Soder, Anja RA Mincheva, Antoaneta RA Lichter, Peter RA Leder, Gerhard RA Gansauge, Frank RA Sorio, Claudio RA Scarpa, Aldo RA Gress, Thomas M. RT "Loss of the Y chromosome is a frequent chromosomal imbalance in RT pancreatic cancer and allows differentiation to chronic RT pancreatitis."; RL Int. J. Cancer 91:340-344(2001). // RX PubMed=20037478; DOI=10.4161/cbt.8.21.9685; PMCID=PMC2824894; RA Kent, Oliver A. RA Mullendore, Michael E. RA Wentzel, Eric A. RA Lopez-Romero, Pedro RA Tan, Aik-Choon RA Alvarez, Hector RA West, Kristen M. RA Ochs, Michael F. RA Hidalgo, Manuel RA Arking, Dan E. RA Maitra, Anirban RA Mendell, Joshua T. RT "A resource for analysis of microRNA expression and function in RT pancreatic ductal adenocarcinoma cells."; RL Cancer Biol. Ther. 8:2013-2024(2009). // RX PubMed=6935474; DOI=10.1093/jnci/66.2.239; RA Wright, William C. RA Daniels, Walter P. RA Fogh, Jorgen RT "Distinction of seventy-one cultured human tumor cell lines by RT polymorphic enzyme analysis."; RL J. Natl. Cancer Inst. 66:239-247(1981). // RX PubMed=27259358; DOI=10.1074/mcp.M116.058313; PMCID=PMC4974343; RA Humphrey, Emily S. RA Su, Shih-Ping RA Nagrial, Adnan M. RA Hochgrafe, Falko RA Pajic, Marina RA Lehrbach, Gillian M. RA Parton, Robert G. RA Yap, Alpha S. RA Horvath, Lisa G. RA Chang, David K. RA Biankin, Andrew Victor RA Wu, Jian-Min RA Daly, Roger John RT "Resolution of novel pancreatic ductal adenocarcinoma subtypes by RT global phosphotyrosine profiling."; RL Mol. Cell. Proteomics 15:2671-2685(2016). // RX PubMed=15770730; DOI=10.3748/wjg.v11.i10.1521; PMCID=PMC4305696; RA Ma, Jian-Hua RA Patrut, Emilia RA Schmidt, Jan RA Knaebel, Hanns-Peter RA Buchler, Markus Wolfgang RA Marten, Alexandra RT "Synergistic effects of interferon-alpha in combination with RT chemoradiation on human pancreatic adenocarcinoma."; RL World J. Gastroenterol. 11:1521-1528(2005). // RX PubMed=8426738; RA Kalthoff, Holger RA Schmiegel, Wolff Helmut RA Roeder, Christian RA Kasche, Daniela RA Schmidt, Andreas RA Lauer, Georg RA Thiele, Heinz-Gunter RA Honold, Georg RA Pantel, Klaus RA Riethmuller, Gert RA Scherer, Ewalt RA Maurer, Julian RA Maacke, Heiko RA Deppert, Wolfgang RT "p53 and K-RAS alterations in pancreatic epithelial cell lesions."; RL Oncogene 8:289-298(1993). // RX DOI=10.4172/jpb.1000057; RA Yamada, Masayo RA Fujii, Kiyonaga RA Koyama, Koji RA Hirohashi, Setsuo RA Kondo, Tadashi RT "The proteomic profile of pancreatic cancer cell lines corresponding RT to carcinogenesis and metastasis."; RL J. Proteomics Bioinformatics 2:1-18(2009). // RX PubMed=7961102; DOI=10.1111/j.1349-7006.1994.tb02898.x; PMCID=PMC5919355; RA Suwa, Hirofumi RA Yoshimura, Tsunehiro RA Yamaguchi, Nozomi RA Kanehira, Kazunori RA Manabe, Tadao RA Imamura, Masayuki RA Hiai, Hiroshi RA Fukumoto, Manabu RT "K-ras and p53 alterations in genomic DNA and transcripts of human RT pancreatic adenocarcinoma cell lines."; RL Jpn. J. Cancer Res. 85:1005-1014(1994). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x; PMCID=PMC3828895; RA Pilarsky, Christian RA Ammerpohl, Ole RA Sipos, Bence RA Dahl, Edgar RA Hartmann, Arndt RA Wellmann, Axel RA Braunschweig, Till RA Lohr, Johannes-Matthias RA Jesenofsky, Ralf RA Friess, Helmut RA Wente, Moritz Nicolas RA Kristiansen, Glen RA Jahnke, Beatrix RA Denz, Axel RA Ruckert, Felix RA Schackert, Hans Konrad RA Kloppel, Gunter RA Kalthoff, Holger RA Saeger, Hans-Detlev RA Grutzmann, Robert RT "Activation of Wnt signalling in stroma from pancreatic cancer RT identified by gene expression profiling."; RL J. Cell. Mol. Med. 12:2823-2835(2008). // RX PubMed=1630814; RA Ruggeri, Bruce Anthony RA Zhang, Shi-Yu RA Caamano, Jorge H. RA DiRado, Marion RA Flynn, Stuart Dale RA Klein-Szanto, Andres J.P. RT "Human pancreatic carcinomas and cell lines reveal frequent and RT multiple alterations in the p53 and Rb-1 tumor-suppressor genes."; RL Oncogene 7:1503-1511(1992). // RX PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720; RA Mattes, Michael Jules RA Cordon-Cardo, Carlos RA Lewis, John L. Jr. RA Old, Lloyd John RA Lloyd, Kenneth Oliver RT "Cell surface antigens of human ovarian and endometrial carcinoma RT defined by mouse monoclonal antibodies."; RL Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984). // RX PubMed=10027410; DOI=10.1016/S0002-9440(10)65298-4; PMCID=PMC1850008; RA Ghadimi, B. Michael RA Schrock, Evelin RA Walker, Robert L. RA Wangsa, Danny RA Jauho, Annukka RA Meltzer, Paul S. RA Ried, Thomas RT "Specific chromosomal aberrations and amplification of the AIB1 RT nuclear receptor coactivator gene in pancreatic carcinomas."; RL Am. J. Pathol. 154:525-536(1999). // RX PubMed=8026879; DOI=10.1002/ijc.2910580207; RA Berrozpe, Georgina RA Schaeffer, James RA Peinado, Miguel Angel RA Real, Francisco X. RA Perucho, Manuel RT "Comparative analysis of mutations in the p53 and K-ras genes in RT pancreatic cancer."; RL Int. J. Cancer 58:185-191(1994). // RX PubMed=7459858; RA Rousset, Monique RA Zweibaum, Alain RA Fogh, Jorgen RT "Presence of glycogen and growth-related variations in 58 cultured RT human tumor cell lines of various tissue origins."; RL Cancer Res. 41:1165-1170(1981). // RX PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123; RA Andersson, Ann-Catrin RA Stromberg, Sara RA Backvall, Helena RA Kampf, Caroline RA Uhlen, Mathias RA Wester, Kenneth RA Ponten, Fredrik RT "Analysis of protein expression in cell microarrays: a tool for RT antibody-based proteomics."; RL J. Histochem. Cytochem. 54:1413-1423(2006). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=8286197; DOI=10.1038/bjc.1994.24; PMCID=PMC1968784; RA Lohr, Johannes-Matthias RA Trautmann, Birgit RA Gottler, Martin RA Peters, Shirley RA Zauner, Ira RA Maillet, Bernard RA Kloppel, Gunter RT "Human ductal adenocarcinomas of the pancreas express extracellular RT matrix proteins."; RL Br. J. Cancer 69:144-151(1994). // RX PubMed=20418756; DOI=10.1097/MPA.0b013e3181c15963; PMCID=PMC2860631; RA Deer, Emily L. RA Gonzalez-Hernandez, Jessica RA Coursen, Jill D. RA Shea, Jill E. RA Ngatia, Josephat Gichuhi RA Scaife, Courtney Lynne RA Firpo, Matthew A. RA Mulvihill, Sean Jordan RT "Phenotype and genotype of pancreatic cancer cell lines."; RL Pancreas 39:425-435(2010). // RX PubMed=7809022; DOI=10.1097/00006676-199409000-00018; RA Sumi, Shoichiro RA Beauchamp, R. Daniel RA Townsend, Courtney M. Jr. RA Pour, Parviz M. RA Ishizuka, Jin RA Thompson, James C. RT "Lovastatin inhibits pancreatic cancer growth regardless of RAS RT mutation."; RL Pancreas 9:657-661(1994). // RX PubMed=25167228; DOI=10.1038/bjc.2014.475; PMCID=PMC4453732; RA Hamidi, Habib RA Lu, Ming RA Chau, Kevin RA Anderson, Lee RA Fejzo, Marlena Schoenberg RA Ginther, Charles RA Linnartz, Ronald RA Zubel, Angela RA Slamon, Dennis Joseph RA Finn, Richard Samuel RT "KRAS mutational subtype and copy number predict in vitro response of RT human pancreatic cancer cell lines to MEK inhibition."; RL Br. J. Cancer 111:1788-1801(2014). // RX PubMed=15367885; DOI=10.1097/00006676-200410000-00004; RA Loukopoulos, Panayiotis RA Kanetaka, Kengo RA Takamura, Masaaki RA Shibata, Tatsuhiro RA Sakamoto, Michiie RA Hirohashi, Setsuo RT "Orthotopic transplantation models of pancreatic adenocarcinoma RT derived from cell lines and primary tumors and displaying varying RT metastatic activity."; RL Pancreas 29:193-203(2004). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=14695172; RA Iacobuzio-Donahue, Christine A. RA Ashfaq, Raheela RA Maitra, Anirban RA Adsay, Nazmi Volkan RA Shen-Ong, Grace L.-C. RA Berg, Karin RA Hollingsworth, Michael Anthony RA Cameron, John Lemuel RA Yeo, Charles J. RA Kern, Scott E. RA Goggins, Michael Gilbert RA Hruban, Ralph H. RT "Highly expressed genes in pancreatic ductal adenocarcinomas: a RT comprehensive characterization and comparison of the transcription RT profiles obtained from three major technologies."; RL Cancer Res. 63:8614-8622(2003). // RX PubMed=1764370; DOI=10.1038/bjc.1991.467; PMCID=PMC1977874; RA Barton, Claire M. RA Staddon, Susan Louise RA Hughes, Christine M. RA Hall, Peter A. RA O'Sullivan, Catriona RA Kloppel, Gunter RA Theis, Belinda RA Russell, Ronald Christopher Gordon RA Neoptolemos, John P. RA Williamson, Robin Charles Noel RA Lane, David Philip RA Lemoine, Nicholas Robert RT "Abnormalities of the p53 tumour suppressor gene in human pancreatic RT cancer."; RL Br. J. Cancer 64:1076-1082(1991). // RX PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396; RA Marcotte, Richard RA Brown, Kevin R. RA Suarez Saiz, Fernando Jose RA Sayad, Azin RA Karamboulas, Konstantina RA Krzyzanowski, Paul M. RA Sircoulomb, Fabrice RA Medrano, Mauricio RA Fedyshyn, Yaroslav RA Koh, Judice Lie-Yong RA van Dyk, Dewald RA Fedyshyn, Bohdana RA Luhova, Marianna RA Brito, Glauber C. RA Vizeacoumar, Franco J. RA Vizeacoumar, Frederick S. RA Datti, Alessandro RA Kasimer, Dahlia RA Buzina, Alla RA Mero, Patricia RA Misquitta, Christine RA Normand, Josee RA Haider, Maliha RA Ketela, Troy RA Wrana, Jeffrey L. RA Rottapel, Robert RA Neel, Benjamin G. RA Moffat, Jason RT "Essential gene profiles in breast, pancreatic, and ovarian cancer RT cells."; RL Cancer Discov. 2:172-189(2012). // RX PubMed=26216984; DOI=10.1073/pnas.1501605112; PMCID=PMC4538616; RA Daemen, Anneleen RA Peterson, David RA Sahu, Nisebita RA McCord, Ron RA Du, Xiang-Nan RA Liu, Bonnie RA Kowanetz, Katarzyna RA Hong, Rebecca RA Moffat, John RA Gao, Min RA Boudreau, Aaron RA Mroue, Rana RA Corson, Laura RA O'Brien, Thomas RA Qing, Jing RA Sampath, Deepak RA Merchant, Mark RA Yauch, Robert L. RA Manning, Gerard RA Settleman, Jeffrey RA Hatzivassiliou, Georgia RA Evangelista, Marie RT "Metabolite profiling stratifies pancreatic ductal adenocarcinomas RT into subtypes with distinct sensitivities to metabolic inhibitors."; RL Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015). // RX PubMed=3518877; DOI=10.3109/07357908609038260; RA Fogh, Jorgen RT "Human tumor lines for cancer research."; RL Cancer Invest. 4:157-184(1986). // RX PubMed=15126341; DOI=10.1158/0008-5472.CAN-03-3159; RA Heidenblad, Markus RA Schoenmakers, Eric F.P.M. RA Jonson, Tord RA Gorunova, Ludmila RA Veltman, Joris Andre RA van Kessel, Ad Geurts RA Hoglund, Mattias RT "Genome-wide array-based comparative genomic hybridization reveals RT multiple amplification targets and novel homozygous deletions in RT pancreatic carcinoma cell lines."; RL Cancer Res. 64:3052-3059(2004). // RX PubMed=8194712; DOI=10.1016/0016-5085(94)90422-7; RA Simon, Babette RA Weinel, Rolf RA Hohne, Martin RA Watz, Jutta RA Schmidt, Jorg RA Kortner, Gunther RA Arnold, Rudolf RT "Frequent alterations of the tumor suppressor genes p53 and DCC in RT human pancreatic carcinoma."; RL Gastroenterology 106:1645-1651(1994). // RX PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x; PMCID=PMC11158928; RA Suzuki, Ayako RA Shibata, Tatsuhiro RA Shimada, Yutaka RA Murakami, Yoshinori RA Horii, Akira RA Shiratori, Keiko RA Hirohashi, Setsuo RA Inazawa, Johji RA Imoto, Issei RT "Identification of SMURF1 as a possible target for 7q21.3-22.1 RT amplification detected in a pancreatic cancer cell line by in-house RT array-based comparative genomic hybridization."; RL Cancer Sci. 99:986-994(2008). // RX PubMed=3019537; RA Kyriazis, Aikaterini A. RA Kyriazis, Andreas P. RA Sternberg, Cora N. RA Sloane, Nathan H. RA Loveless, James D. RT "Morphological, biological, biochemical, and karyotypic RT characteristics of human pancreatic ductal adenocarcinoma Capan-2 in RT tissue culture and the nude mouse."; RL Cancer Res. 46:5810-5815(1986). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163; RA Okamoto, Aikou RA Demetrick, Douglas J. RA Spillare, Elisa A. RA Hagiwara, Koichi RA Hussain, S. Perwez RA Bennett, William P. RA Forrester, Kathleen RA Gerwin, Brenda Isen RA Serrano, Manuel RA Beach, David H. RA Harris, Curtis Craig RT "Mutations and altered expression of p16INK4 in human cancer."; RL Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994). // RX PubMed=31037374; DOI=10.1007/s00216-019-01814-1; RA Lagies, Simon RA Schlimpert, Manuel RA Braun, Lukas M. RA Kather, Michel RA Plagge, Johannes RA Erbes, Thalia RA Wittel, Uwe A. RA Kammerer, Bernd RT "Unraveling altered RNA metabolism in pancreatic cancer cells by RT liquid-chromatography coupling to ion mobility mass spectrometry."; RL Anal. Bioanal. Chem. 411:6319-6328(2019). // RX PubMed=15688027; DOI=10.1038/sj.onc.1208383; RA Heidenblad, Markus RA Lindgren, David RA Veltman, Joris Andre RA Jonson, Tord RA Mahlamaki, Eija H. RA Gorunova, Ludmila RA van Kessel, Ad Geurts RA Schoenmakers, Eric F.P.M. RA Hoglund, Mattias RT "Microarray analyses reveal strong influence of DNA copy number RT alterations on the transcriptional patterns in pancreatic cancer: RT implications for the interpretation of genomic amplifications."; RL Oncogene 24:1794-1801(2005). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). //