ID   KM-3
AC   CVCL_0011
SY   KM3; Km3
DR   BTO; BTO_0000681
DR   BioSample; SAMN03151905
DR   cancercelllines; CVCL_0011
DR   Wikidata; Q54900042
RX   PubMed=68013;
RX   PubMed=204546;
RX   PubMed=2985879;
RX   PubMed=3159941;
RX   PubMed=3874327;
RX   PubMed=6954533;
RX   PubMed=12592342;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a Reh derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from a 12 year old male patient with acute lymphoblastic leukemia.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00226.
CC   Sequence variation: Gene fusion; HGNC; HGNC:3495; ETV6 + HGNC; HGNC:10471; RUNX1; Name(s)=ETV6-RUNX1, TEL-AML1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg173Cys (c.517C>T); ClinVar=VCV000189500; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg181Cys (c.541C>T); ClinVar=VCV000142624; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80334; B lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) ETV6-RUNX1
DI   ORDO; Orphanet_585929; B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1650 ! Reh
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
//
RX   PubMed=68013; DOI=10.1002/ijc.2910190505;
RA   Schneider U., Schwenk H.-U., Bornkamm G.-W.;
RT   "Characterization of EBV-genome negative 'null' and 'T' cell lines
RT   derived from children with acute lymphoblastic leukemia and leukemic
RT   transformed non-Hodgkin lymphoma.";
RL   Int. J. Cancer 19:621-626(1977).
//
RX   PubMed=204546; DOI=10.1007/978-3-642-66639-1_32;
RA   Schneider U., Schwenk H.-U.;
RT   "Characterization of 'T' and 'non-T' cell lines established from
RT   children with acute lymphoblastic leukemia and non-Hodgkin lymphoma
RT   after leukemic transformation.";
RL   Haematol. Blood Transfus. 20:265-269(1977).
//
RX   PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0;
RA   Drexler H.G., Gaedicke G., Minowada J.;
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1.
RT   Carboxylic esterase.";
RL   Leuk. Res. 9:209-229(1985).
//
RX   PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1;
RA   Drexler H.G., Gaedicke G., Minowada J.;
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- III.
RT   Beta-hexosaminidase (E.C. 3.2.1.30).";
RL   Leuk. Res. 9:549-559(1985).
//
RX   PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x;
RA   Drexler H.G., Gaedicke G., Minowada J.;
RT   "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid
RT   phosphatase.";
RL   Leuk. Res. 9:537-548(1985).
//
RX   PubMed=6954533; DOI=10.1073/pnas.79.7.2194; PMCID=PMC346157;
RA   Westin E.H., Gallo R.C., Arya S.K., Eva A., Souza L.M., Baluda M.A.,
RA   Aaronson S.A., Wong-Staal F.;
RT   "Differential expression of the amv gene in human hematopoietic
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.;
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//