ID   HDLM-2
AC   CVCL_0009
SY   HD-LM-2; HDLM2
DR   CLO; CLO_0003671
DR   CLDB; cl1580
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioSample; SAMN03473364
DR   BioSample; SAMN10988513
DR   cancercelllines; CVCL_0009
DR   Cell_Model_Passport; SIDM01064
DR   ChEMBL-Cells; CHEMBL3308234
DR   ChEMBL-Targets; CHEMBL2366231
DR   Cosmic; 924110
DR   Cosmic; 988701
DR   Cosmic; 1013909
DR   Cosmic; 1086355
DR   Cosmic; 1278832
DR   Cosmic; 1289699
DR   Cosmic; 1290220
DR   Cosmic; 1432040
DR   Cosmic; 2276322
DR   Cosmic; 2464309
DR   Cosmic-CLP; 924110
DR   DepMap; ACH-000267
DR   DSMZ; ACC-17
DR   DSMZCellDive; ACC-17
DR   EGA; EGAS00001000978
DR   GDSC; 924110
DR   GEO; GSM335390
DR   GEO; GSM381298
DR   GEO; GSM499724
DR   GEO; GSM499732
DR   GEO; GSM552430
DR   GEO; GSM646534
DR   GEO; GSM887064
DR   GEO; GSM888134
DR   GEO; GSM1669870
DR   GEO; GSM7701399
DR   IARC_TP53; 23613
DR   IGRhCellID; HDLM2
DR   LINCS_LDP; LCL-2007
DR   PharmacoDB; HDLM2_521_2019
DR   PRIDE; PXD000589
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0009
DR   PubChem_Cell_line; CVCL_0009
DR   Wikidata; Q54882175
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2602652;
RX   PubMed=2690233;
RX   PubMed=3713248;
RX   PubMed=8558920;
RX   PubMed=9685479;
RX   PubMed=12581897;
RX   PubMed=16957166;
RX   PubMed=17065008;
RX   PubMed=19380639;
RX   PubMed=20164919;
RX   PubMed=20628145;
RX   PubMed=22460905;
RX   PubMed=25894527;
RX   PubMed=27397505;
RX   PubMed=29533902;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
RX   PubMed=35839778;
WW   Info; HPA; -; https://www.proteinatlas.org/learn/cellines
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: Human Protein Atlas, Cell Atlas panel.
CC   Part of: LL-100 blood cancer cell line panel.
CC   Population: Caucasian.
CC   Doubling time: ~70-75 hours (DSMZ=ACC-17).
CC   HLA typing: A*01:01:01,02:01:01; B*08:01:01,44:02:01; C*05:01:01,07:01:01; DPA1*01:03:01,01:03:01; DPB1*03:01:01,04:01:01; DQA1*01:02:01,01:03:01; DQB1*06:02:01,06:03:01; DRA*01:02:02,01:02:03; DRB1*13:01:01,15:01:01 (DSMZCellDive=ACC-17).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene deletion; HGNC; HGNC:11896; TNFAIP3; Zygosity=Heterozygous (PubMed=19380639).
CC   Sequence variation: Mutation; HGNC; HGNC:11896; TNFAIP3; Simple; p.Met174fs (c.520_548dup) (dup 586-614); Zygosity=Heterozygous (PubMed=19380639).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Unexplicit; Fusion with an Alu-element at the Ex7-Ex8 junction; Zygosity=Unspecified (PubMed=17065008).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Large antibody panel staining analysis.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Proteomics; Subcellular; Cell surface.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.09%; Native American=0%; East Asian, North=1.64%; East Asian, South=0%; South Asian=0.05%; European, North=62.14%; European, South=35.08% (PubMed=30894373).
CC   Misspelling: HDML-2; PubMed=16957166.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): Cosmic-CLP=924110; DSMZ=ACC-17
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 12
ST   D18S51: 14
ST   D19S433: 12,15
ST   D21S11: 29
ST   D2S1338: 17
ST   D3S1358: 14,15
ST   D5S818: 11
ST   D7S820: 8,10
ST   D8S1179: 13,14
ST   FGA: 21,23
ST   Penta D: 13,14
ST   Penta E: 12
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 19
DI   NCIt; C9357; Hodgkin lymphoma
DI   ORDO; Orphanet_98293; Hodgkin lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_M693 ! HDLM-1
OI   CVCL_M697 ! HDLM-3
SX   Male
AG   74Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 44
CH   CVCL_M696 ! HDLM-2d
//
RX   PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356;
RA   Green, Michael Richard
RA   Monti, Stefano
RA   Rodig, Scott J.
RA   Juszczynski, Przemyslaw
RA   Currie, Treeve
RA   O'Donnell, Evan
RA   Chapuy, Bjoern
RA   Takeyama, Kunihiko
RA   Neuberg, Donna
RA   Golub, Todd Robert
RA   Kutok, Jeffery L.
RA   Shipp, Margaret Ann
RT   "Integrative analysis reveals selective 9p24.1 amplification,
RT   increased PD-1 ligand expression, and further induction via JAK2 in
RT   nodular sclerosing Hodgkin lymphoma and primary mediastinal large
RT   B-cell lymphoma.";
RL   Blood 116:3268-3277(2010).
//
RX   PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5;
RA   Schaadt, Michael
RA   Burrichter, Heinz
RA   Pfreundschuh, Michael
RA   Schell-Frederick, Elizabeth
RA   Tesch, Hans
RA   Fonatsch, Christa
RA   Stein, Harald
RA   Diehl, Volker
RT   "Biology of Hodgkin cell lines.";
RL   Recent Results Cancer Res. 117:53-61(1989).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347;
RA   Bausch-Fluck, Damaris
RA   Hofmann, Andreas
RA   Bock, Thomas
RA   Frei, Andreas P.
RA   Cerciello, Ferdinando
RA   Jacobs, Andrea
RA   Moest, Hansjoerg
RA   Omasits, Ulrich
RA   Gundry, Rebekah L.
RA   Yoon, Charles
RA   Schiess, Ralph
RA   Schmidt, Alexander
RA   Mirkowska, Paulina
RA   Hartlova, Anetta Svitorka
RA   Van Eyk, Jennifer Eileen
RA   Bourquin, Jean-Pierre
RA   Aebersold, Ruedi
RA   Boheler, Kenneth R.
RA   Zandstra, Peter W.
RA   Wollscheid, Bernd
RT   "A mass spectrometric-derived cell surface protein atlas.";
RL   PLoS ONE 10:e0121314.1-e0121314.22(2015).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Dirks, Wilhelm Gerhard
RA   Eberth, Sonja
RA   Koeppel, Max
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Steube, Klaus G.
RA   Uphoff, Cord C.
RA   Drexler, Hans Gunther
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218.1-8218.14(2019).
//
RX   PubMed=8558920;
RA   Dirks, Wilhelm Gerhard
RA   Zaborski, Margarete
RA   Jager, Kathrin
RA   Challier, Cecile
RA   Shiota, Mami
RA   Quentmeier, Hilmar
RA   Drexler, Hans Gunther
RT   "The (2;5)(p23;q35) translocation in cell lines derived from malignant
RT   lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.";
RL   Leukemia 10:142-149(1996).
//
RX   PubMed=9685479; DOI=10.1093/nar/26.16.3651; PMCID=PMC147775;
RA   Hultdin, Magnus
RA   Gronlund, Elisabeth
RA   Norrback, Karl-Frederik
RA   Eriksson-Lindstrom, E.
RA   Just, Tom
RA   Roos, Goran
RT   "Telomere analysis by fluorescence in situ hybridization and flow
RT   cytometry.";
RL   Nucleic Acids Res. 26:3651-3656(1998).
//
RX   PubMed=12581897; DOI=10.1016/S0165-4608(02)00656-8;
RA   Berglund, Mattias
RA   Flordal, Emma
RA   Gullander, Jacob
RA   Lui, Weng-Onn
RA   Larsson, Catharina
RA   Lagercrantz, Svetlana
RA   Enblad, Gunilla
RT   "Molecular cytogenetic characterization of four commonly used cell
RT   lines derived from Hodgkin lymphoma.";
RL   Cancer Genet. Cytogenet. 141:43-48(2003).
//
RX   PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123;
RA   Andersson, Ann-Catrin
RA   Stromberg, Sara
RA   Backvall, Helena
RA   Kampf, Caroline
RA   Uhlen, Mathias
RA   Wester, Kenneth
RA   Ponten, Fredrik
RT   "Analysis of protein expression in cell microarrays: a tool for
RT   antibody-based proteomics.";
RL   J. Histochem. Cytochem. 54:1413-1423(2006).
//
RX   PubMed=17065008; DOI=10.1080/10428190600667721;
RA   Feuerborn, Alexander
RA   Moritz, Constanze
RA   von Bonin, Frederike
RA   Dobbelstein, Matthias
RA   Trumper, Lorenz
RA   Sturzenhofecker, Benjamin
RA   Kube, Dieter
RT   "Dysfunctional p53 deletion mutants in cell lines derived from
RT   Hodgkin's lymphoma.";
RL   Leuk. Lymphoma 47:1932-1940(2006).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=19380639; DOI=10.1084/jem.20090528; PMCID=PMC2715030;
RA   Schmitz, Roland
RA   Hansmann, Martin-Leo
RA   Bohle, Verena
RA   Martin-Subero, Jose Ignacio
RA   Hartmann, Sylvia
RA   Mechtersheimer, Gunhild
RA   Klapper, Wolfram
RA   Vater, Inga
RA   Giefing, Maciej
RA   Gesk, Stefan
RA   Stanelle, Jens
RA   Siebert, Reiner
RA   Kuppers, Ralf
RT   "TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and
RT   primary mediastinal B cell lymphoma.";
RL   J. Exp. Med. 206:981-989(2009).
//
RX   PubMed=2602652; DOI=10.1007/978-3-642-83781-4_8;
RA   Drexler, Hans Gunther
RA   Gignac, Suzanne M.
RA   Hoffbrand, Allan Victor
RA   Leber, Brian Frederick
RA   Norton, John D.
RA   Lok, Ming-Swang
RA   Minowada, Jun
RT   "Characterization of Hodgkin's disease derived cell line HDLM-2.";
RL   Recent Results Cancer Res. 117:75-82(1989).
//
RX   PubMed=29533902; DOI=10.1515/hsz-2017-0321;
RA   Drexler, Hans Gunther
RA   Pommerenke, Claudia
RA   Eberth, Sonja
RA   Nagel, Stefan
RT   "Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
RL   Biol. Chem. 399:511-523(2018).
//
RX   PubMed=3713248; DOI=10.1016/0145-2126(86)90084-6;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Lok, Ming-Swang
RA   Diehl, Volker
RA   Minowada, Jun
RT   "Hodgkin's disease derived cell lines HDLM-2 and L-428: comparison of
RT   morphology, immunological and isoenzyme profiles.";
RL   Leuk. Res. 10:487-500(1986).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//