ID HEL AC CVCL_0001 SY Hel; GM06141; GM06141B; Human ErythroLeukemia DR BTO; BTO_0000565 DR CLO; CLO_0003679 DR CLO; CLO_0023565 DR EFO; EFO_0006579 DR MCCL; MCC:0000187 DR CLDB; cl0 DR CLDB; cl1585 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ArrayExpress; E-MTAB-7721 DR ArrayExpress; E-MTAB-7722 DR BioGRID_ORCS_Cell_line; 210 DR BioSample; SAMN03471056 DR BioSample; SAMN03472269 DR BioSample; SAMN10987697 DR cancercelllines; CVCL_0001 DR CCRID; 3101HUMTCHu71 DR CCRID; 4201HUM-CCTCC00071 DR CCTCC; GDC0071 DR Cell_Model_Passport; SIDM00594 DR ChEMBL-Cells; CHEMBL3308090 DR ChEMBL-Targets; CHEMBL613888 DR CLS; 305022 DR Coriell; GM06141 DR Cosmic; 787432 DR Cosmic; 798663 DR Cosmic; 850392 DR Cosmic; 907053 DR Cosmic; 919128 DR Cosmic; 924040 DR Cosmic; 947363 DR Cosmic; 975251 DR Cosmic; 976722 DR Cosmic; 994176 DR Cosmic; 996314 DR Cosmic; 1012051 DR Cosmic; 1013868 DR Cosmic; 1037665 DR Cosmic; 1070698 DR Cosmic; 1078733 DR Cosmic; 1122162 DR Cosmic; 1127268 DR Cosmic; 1139508 DR Cosmic; 1139638 DR Cosmic; 1140092 DR Cosmic; 1151879 DR Cosmic; 1168467 DR Cosmic; 1170892 DR Cosmic; 1171333 DR Cosmic; 1176583 DR Cosmic; 1191710 DR Cosmic; 1192825 DR Cosmic; 1601067 DR Cosmic; 1604866 DR Cosmic; 1633512 DR Cosmic; 1943609 DR Cosmic; 2089667 DR Cosmic; 2131538 DR Cosmic; 2306207 DR Cosmic; 2649243 DR Cosmic-CLP; 907053 DR DepMap; ACH-000004 DR DSMZ; ACC-11 DR DSMZCellDive; ACC-11 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR EGA; EGAS00001002554 DR GDSC; 907053 DR GEO; GSM482506 DR GEO; GSM743410 DR GEO; GSM887077 DR GEO; GSM888147 DR GEO; GSM1028243 DR GEO; GSM1446763 DR GEO; GSM1669874 DR GEO; GSM7701373 DR GEO; GSM7701374 DR IARC_TP53; 21368 DR JCRB; JCRB0062 DR KCB; KCB 200808YJ DR LiGeA; CCLE_453 DR LINCS_LDP; LCL-1053 DR PharmacoDB; HEL_534_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_0001 DR PubChem_Cell_line; CVCL_0001 DR Ubigene; YC-C090 DR Wikidata; Q54882501 RX CelloPub=CLPUB00447; RX DOI=10.1007/978-1-4757-1647-4_13; RX PubMed=2985879; RX PubMed=3159941; RX PubMed=3874327; RX PubMed=6177045; RX PubMed=7538619; RX PubMed=8558913; RX PubMed=9290701; RX PubMed=9510473; RX PubMed=9738977; RX PubMed=10739008; RX PubMed=11021758; RX PubMed=11226526; RX PubMed=14504097; RX PubMed=16408098; RX PubMed=16957166; RX PubMed=20164919; RX PubMed=22460905; RX PubMed=23955599; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27277069; RX PubMed=27397505; RX PubMed=29533902; RX PubMed=30285677; RX PubMed=30629668; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31160637; RX PubMed=31978347; RX PubMed=35839778; RX PubMed=36982453; WW Info; HPA; -; https://www.proteinatlas.org/learn/cellines WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-346.html WW Info; Wikipedia; -; https://en.wikipedia.org/wiki/HEL_cell_line CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: Human Protein Atlas, Cell Atlas panel. CC Part of: LL-100 blood cancer cell line panel. CC Population: Caucasian. CC Doubling time: ~24 hours (PubMed=6177045); 17.8 +- 1.8 hours (Note=In serum-containing medium), 23.3 +- 0.8 hours (Note=In serum-free medium) (PubMed=7538619); ~36 hours (DSMZ=ACC-11). CC HLA typing: A*03:01,32:01; B*35:08,35:08; C*04:01,04:01; DQA1*05:01,05:01; DRB1*03:38,13:03 (PubMed=26589293). CC HLA typing: A*03:01:01,32:01:01; B*35:08:01,35:01:01; C*04:01:01,04:01:01; DPA1*01:03:01,01:03:01; DPB1*04:01:01,02:01:02 (DSMZCellDive=ACC-11). CC Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous (PubMed=16408098). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met133Lys (c.398T>A); ClinVar=VCV002430159; Zygosity=Homozygous (Cosmic-CLP=907053; DepMap=ACH-000004). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Large antibody panel staining analysis. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=2.4%; Native American=1.79%; East Asian, North=3.9%; East Asian, South=0%; South Asian=5.12%; European, North=13.33%; European, South=73.45% (PubMed=30894373). CC Donor information: Originally the patient was suffering from Hodgkin lymphoma. CC Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. CC Cell type: Erythroblast; CL=CL_0000765. ST Source(s): CCRID; Cosmic-CLP=907053; COG; DSMZ=ACC-11; JCRB=JCRB0062; PubMed=25877200; Technion Genomics Center ST Amelogenin: X (CCRID; Cosmic-CLP=907053; JCRB=JCRB0062) ST Amelogenin: X,Y (COG; DSMZ=ACC-11; PubMed=25877200; Technion Genomics Center) ST CSF1PO: 10 (Cosmic-CLP=907053; COG; DSMZ=ACC-11; JCRB=JCRB0062; PubMed=25877200; Technion Genomics Center) ST CSF1PO: 10,11 (CCRID) ST D10S1248: 13 ST D12S391: 18,21 ST D13S317: 9,11 ST D16S539: 11 ST D18S51: 12,16 (CCRID; DSMZ=ACC-11; PubMed=25877200; Technion Genomics Center) ST D18S51: 16 (COG) ST D19S433: 11,13 ST D1S1656: 17.3 ST D21S11: 29,30.2 (DSMZ=ACC-11; PubMed=25877200; Technion Genomics Center) ST D21S11: 29,30.2,31.2 (CCRID; COG) ST D22S1045: 15,16 ST D2S1338: 18,19 ST D2S441: 10,15 ST D3S1358: 15 ST D5S818: 11 ST D7S820: 7 ST D8S1179: 13,15 ST DYS391: 10 ST FGA: 21,22,23 (CCRID) ST FGA: 22,23 (COG; DSMZ=ACC-11; PubMed=25877200; Technion Genomics Center) ST Penta D: 11,13 ST Penta E: 13,18 ST TH01: 7 ST TPOX: 11 ST vWA: 14,17 DI NCIt; C7152; Erythroleukemia DI ORDO; Orphanet_318; Acute erythroid leukemia OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 30Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 49 CH CVCL_KS72 ! CellSensor irf1-bla HEL CH CVCL_4360 ! Dami CH CVCL_2481 ! HEL 92.1.7 CH CVCL_A5ZL ! HEL-N1 CH CVCL_A5ZM ! HEL-P1 CH CVCL_RS48 ! HELrARA-C2mug/ML CH CVCL_D9W4 ! Ubigene HEL BCL2L1 KO // RX PubMed=7538619; DOI=10.1016/0145-2126(94)00160-c; RA Kubota, Akira RA Okamura, Seiichi RA Shimoda, Kazuya RA Ikematsu, Wataru RA Otsuka, Teruhisa RA Niho, Yoshiyuki RT "Analysis of c-kit expression of human erythroleukemia cell line, HEL: RT clonal variation and relationship with erythroid and megakaryocytic RT phenotype."; RL Leuk. Res. 19:283-290(1995). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=23955599; DOI=10.1038/ng.2731; RA Kon, Ayana RA Shih, Lee-Yung RA Minamino, Masashi RA Sanada, Masashi RA Shiraishi, Yuichi RA Nagata, Yasunobu RA Yoshida, Ken-ichi RA Okuno, Yusuke RA Bando, Masashige RA Nakato, Ryuichiro RA Ishikawa, Shumpei RA Sato-Otsubo, Aiko RA Nagae, Genta RA Nishimoto, Aiko RA Haferlach, Claudia RA Nowak, Daniel RA Sato, Yusuke RA Alpermann, Tamara RA Nagasaki, Masao RA Shimamura, Teppei RA Tanaka, Hiroko RA Chiba, Kenichi RA Yamamoto, Ryo RA Yamaguchi, Tomoyuki RA Otsu, Makoto RA Obara, Naoshi RA Sakata-Yanagimoto, Mamiko RA Nakamaki, Tsuyoshi RA Ishiyama, Ken RA Nolte, Florian RA Hofmann, Wolf-Karsten RA Miyawaki, Shuichi RA Chiba, Shigeru RA Mori, Hiraku RA Nakauchi, Hiromitsu RA Koeffler, Harold Phillip RA Aburatani, Hiroyuki RA Haferlach, Torsten RA Shirahige, Katsuhiko RA Miyano, Satoru RA Ogawa, Seishi RT "Recurrent mutations in multiple components of the cohesin complex in RT myeloid neoplasms."; RL Nat. 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RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D; RA Jia, Li-Qun RA Osada, Motonobu RA Ishioka, Chikashi RA Gamo, Makio RA Ikawa, Shuntaro RA Suzuki, Takao RA Shimodaira, Hideki RA Niitani, Tomohito RA Kudo, Toshio RA Akiyama, Mitoshi RA Kimura, Narimiti RA Matsuo, Mitsuyoshi RA Mizusawa, Hiroshi RA Tanaka, Noriho RA Koyama, Hideki RA Namba, Masayoshi RA Kanamaru, Ryunosuke RA Kuroki, Toshio RT "Screening the p53 status of human cell lines using a yeast functional RT assay."; RL Mol. 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RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=14504097; DOI=10.1182/blood-2003-02-0418; RA Taketani, Takeshi RA Taki, Tomohiko RA Sugita, Kanji RA Furuichi, Yoshiyuki RA Ishii, Eiichi RA Hanada, Ryoji RA Tsuchida, Masahiro RA Sugita, Kenichi RA Ida, Kohmei RA Hayashi, Yasuhide RT "FLT3 mutations in the activation loop of tyrosine kinase domain are RT frequently found in infant ALL with MLL rearrangements and pediatric RT ALL with hyperdiploidy."; RL Blood 103:1085-1088(2004). // RX PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. RT Carboxylic esterase."; RL Leuk. Res. 9:209-229(1985). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. 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RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff, Cord C. RA Pommerenke, Claudia RA Denkmann, Sabine A. RA Drexler, Hans Gunther RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Frequent microsatellite instability and BAX mutations in T cell acute RT lymphoblastic leukemia cell lines."; RL Leuk. 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