ID   RUD
AC   CVCL_ZI13
SY   Raji(Brdu)
DR   cancercelllines; CVCL_ZI13
DR   Wikidata; Q98129216
RX   PubMed=4550511;
RX   PubMed=6278187;
RX   PubMed=6278188;
CC   Population: African; Nigerian.
CC   Selected for resistance to: ChEBI; CHEBI:472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR).
CC   Sequence variation: Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0511 ! Raji
SX   Male
AG   11Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 02-05-24; Version: 9
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RX   PubMed=4550511; DOI=10.1073/pnas.69.1.78; PMCID=PMC427548;
RA   Hampar B., Derge J.G., Martos L.M., Walker J.L.;
RT   "Synthesis of Epstein-Barr virus after activation of the viral genome
RT   in a 'virus-negative' human lymphoblastoid cell (Raji) made resistant
RT   to 5-bromodeoxyuridine.";
RL   Proc. Natl. Acad. Sci. U.S.A. 69:78-82(1972).
//
RX   PubMed=6278187; DOI=10.1093/jnci/68.2.179;
RA   Zeuthen J., Klein G., Ber R., Masucci G., Bisballe S., Povey S.,
RA   Terasaki P.I., Ralph P.;
RT   "Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. I.
RT   Isolation, characterization, cell surface markers, and B-cell
RT   markers.";
RL   J. Natl. Cancer Inst. 68:179-195(1982).
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RX   PubMed=6278188; DOI=10.1093/jnci/68.2.197;
RA   Klein G., Zeuthen J., Ber R., Ernberg I.;
RT   "Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. II.
RT   Epstein-Barr virus induction patterns.";
RL   J. Natl. Cancer Inst. 68:197-202(1982).
//