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Cellosaurus NCC-MPNST4-C1 (CVCL_YU16)

[Text version]
Cell line name NCC-MPNST4-C1
Synonyms NCCMPNST4C1
Accession CVCL_YU16
Resource Identification Initiative To cite this cell line use: NCC-MPNST4-C1 (RRID:CVCL_YU16)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCC sarcoma cell line panel.
Population: Japanese.
Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo, Tadashi).
Doubling time: 70 hours (PubMed=32099531).
Sequence variations
  • Gene deletion; HGNC; 646; ARAF; Zygosity=Homozygous (PubMed=32099531).
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=32099531).
  • Gene deletion; HGNC; 12637; KDM6A; Zygosity=Homozygous (PubMed=32099531).
  • Mutation; HGNC; 7765; NF1; Simple; c.5812+3delAGTA; Zygosity=Heterozygous (PubMed=32099531).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg249Gly (c.745A>G); ClinVar=VCV000376654; Zygosity=Homozygous (PubMed=32099531).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): PubMed=32099531

Markers:
AmelogeninX,Y
CSF1PO12
D5S81812
D7S82011
D13S31710
D16S5399
D21S1130
TH016
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages https://en.cellline.jp/product/ncc-mpnst4-c1/
Publications

PubMed=32099531; DOI=10.1186/s12935-020-1128-z; PMCID=PMC7031935
Oyama R., Kito F., Takahashi M., Hattori E., Noguchi R., Takai Y., Sakumoto M., Qiao Z.-W., Toki S., Sugawara M., Tanzawa Y., Kobayashi E., Nakatani F., Iwata S., Yoshida A., Kawai A., Kondo T.
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors.
Cancer Cell Int. 20:58.1-58.15(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YU16
DepMap; ACH-002803
Encyclopedic resources Wikidata; Q95992538
Entry history
Entry creation12-Mar-2020
Last entry update10-Sep-2024
Version number10