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Cellosaurus ICC5 (CVCL_VV28)

[Text version]
Cell line name ICC5
Accession CVCL_VV28
Resource Identification Initiative To cite this cell line use: ICC5 (RRID:CVCL_VV28)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 5 days (Direct_author_submission).
Miscellaneous: Doubling time and age/sex of donor from personal communication of El-Bardeesy, Nabeel.
Sequence variations
  • Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Val (c.394_395CG>GT); Zygosity=Unspecified (PubMed=27231123; DepMap=ACH-001845).
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001845

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135814
D5S81812,13
D7S82010
D8S117914
D13S3179,14
D16S53913
D18S5115,17
D21S1128,32.2
FGA23,25
Penta D10,11
Penta E9,11
TH019,10
TPOX8
vWA21

Run an STR similarity search on this cell line
Publications

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442; PMCID=PMC5458737
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X.-X., Joung J.K., Shokat K.M., Benes C.H., El-Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y., Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S., Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VV28
Cell_Model_Passport; SIDM01803
DepMap; ACH-001845
Encyclopedic resources Wikidata; Q94313317
Entry history
Entry creation24-May-2019
Last entry update10-Sep-2024
Version number11