ID   R/VP-16
AC   CVCL_UJ12
DR   cancercelllines; CVCL_UJ12
DR   Wikidata; Q98128775
RX   CelloPub=CLPUB00458;
RX   PubMed=8099376;
CC   Population: African; Nigerian.
CC   Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
CC   Sequence variation: Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0511 ! Raji
SX   Male
AG   11Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 02-05-24; Version: 12
//
RX   CelloPub=CLPUB00458;
RA   Treichel R.S.;
RT   "Susceptibility to LAK-mediated cytotoxicity of multidrug-resistant
RT   variants of the human RAJI cell line is not related to expression of
RT   major cellular adhesion molecules.";
RL   Ohio J. Sci. 93:14-18(1993).
//
RX   PubMed=8099376; DOI=10.1016/0145-2126(93)90124-4;
RA   Treichel R.S.;
RT   "Autologous bone marrow transplantation for leukemia: monoclonal
RT   antibody-mediated purging of multidrug-resistant leukemia.";
RL   Leuk. Res. 17:491-499(1993).
//