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Cellosaurus T24T FL3 (CVCL_M897)

[Text version]
Cell line name T24T FL3
Synonyms FL3
Accession CVCL_M897
Resource Identification Initiative To cite this cell line use: T24T FL3 (RRID:CVCL_M897)
Comments Part of: BLA-40 bladder carcinoma cell line panel.
Population: Caucasian; Swedish.
Characteristics: Forms metastasis in the lung of mice. Produced by passage of the parent cell line through nude mice.
Omics: Exosome proteome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_M896 (T24T FL2)
Children:
CVCL_RN62 (T24T FL4)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Publications

PubMed=15520187; DOI=10.1158/0008-5472.CAN-04-0826
Nicholson B.E., Frierson H.F. Jr., Conaway M.R., Seraj J.M., Harding M.A., Hampton G.M., Theodorescu D.
Profiling the evolution of human metastatic bladder cancer.
Cancer Res. 64:7813-7821(2004)

PubMed=19147813; DOI=10.2353/ajpath.2009.080538; PMCID=PMC2630547
Smith S.C., Nicholson B., Nitz M.D., Frierson H.F. Jr., Smolkin M., Hampton G.M., El-Rifai W., Theodorescu D.
Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination.
Am. J. Pathol. 174:371-379(2009)

PubMed=24376083; DOI=10.1002/pmic.201300452
Jeppesen D.K., Nawrocki A., Jensen S.G., Thorsen K., Whitehead B., Howard K.A., Dyrskjot L., Orntoft T.F., Larsen M.R., Ostenfeld M.S.
Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors.
Proteomics 14:699-712(2014)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M897
Encyclopedic resources Wikidata; Q54971472
Gene expression databases GEO; GSM136264
Entry history
Entry creation05-Nov-2013
Last entry update05-Oct-2023
Version number15