ID   MCF-7/RU58R-1
AC   CVCL_K235
SY   MCF-7/RU58(R)-1; RU58(R)-1; RU58R-1
DR   cancercelllines; CVCL_K235
DR   Wikidata; Q54904378
RX   PubMed=15868441;
RX   PubMed=16172194;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:90223; RU 58668.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 19
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RX   PubMed=15868441; DOI=10.1007/s10549-004-5871-y;
RA   Fog C.K., Christensen I.J., Lykkesfeldt A.E.;
RT   "Characterization of a human breast cancer cell line, MCF-7/RU58R-1,
RT   resistant to the pure antiestrogen RU 58,668.";
RL   Breast Cancer Res. Treat. 91:133-144(2005).
//
RX   PubMed=16172194; DOI=10.1677/erc.1.00946;
RA   Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L.,
RA   Lykkesfeldt A.E.;
RT   "Antiestrogen-resistant human breast cancer cells require activated
RT   protein kinase B/Akt for growth.";
RL   Endocr. Relat. Cancer 12:599-614(2005).
//