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Cellosaurus A375-ER-2 (CVCL_C8YB)

[Text version]
Cell line name A375-ER-2
Synonyms A375 SKIN CJ2; A375-CJ2
Accession CVCL_C8YB
Resource Identification Initiative To cite this cell line use: A375-ER-2 (RRID:CVCL_C8YB)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Johannessen, Cory M.; Broad Institute of MIT and Harvard; Harvard; USA.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:167670; SCH772984.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01937
DepMap; ACH-002002
Encyclopedic resources Wikidata; Q123030357
Entry history
Entry creation05-Oct-2023
Last entry update10-Sep-2024
Version number4