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Cellosaurus OMM2.5 (CVCL_C307)

[Text version]
Cell line name OMM2.5
Synonyms Omm2.5; OMM2_5; OMM25; OMM1.5; Omm1_5
Accession CVCL_C307
Resource Identification Initiative To cite this cell line use: OMM2.5 (RRID:CVCL_C307)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Ksander, Bruce R.; Schepens Eye Research Institute; Boston; USA.
Doubling time: 50 hours (PubMed=24994677).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 4390; GNAQ; Simple; p.Gln209Pro (c.626A>C); ClinVar=VCV000375957; Zygosity=Unspecified (PubMed=22236444).
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C302 ! Mel270
CVCL_C305 ! OMM2.2
CVCL_C306 ! OMM2.3
CVCL_C308 ! OMM2.6
Sex of cell Male
Category Cancer cell line
STR profile Source(s): DepMap=ACH-002018; PubMed=22236444; PubMed=24994677

Markers:
AmelogeninX,Y
CSF1PO11
D3S135816
D5S81812
D7S8208,9
D8S11798,13
D13S31712
D16S53912
D18S5119
D21S1128,29
FGA26 (PubMed=22236444)
26,27 (DepMap=ACH-002018)
Penta D15,16
Penta E8,10
TH016,9
TPOX10
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=9247253; DOI=10.1023/A:1018479011340
Chen P.W., Murray T.G., Uno T., Salgaller M.L., Reddy R., Ksander B.R.
Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease.
Clin. Exp. Metastasis 15:509-518(1997)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394
Griewank K.G., Yu X.-X., Khalili J.S., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011
Amaro A., Mirisola V., Angelini G., Musso A., Tosetti F.I., Esposito A.I., Perri P., Lanza F.B., Nasciuti F., Mosci C., Puzone R., Salvi S., Truini M., Poggi A., Pfeffer U.
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.
Eur. J. Cancer 49:3353-3365(2013)

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Amirouchene-Angelozzi N., Nemati F., Gentien D., Nicolas A., Dumont A., Carita G., Camonis J., Desjardins L., Cassoux N., Piperno-Neumann S., Mariani P., Sastre-Garau X., Decaudin D., Roman-Roman S.
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

PubMed=28018010; PMCID=PMC5161001
Jager M.J., Bermudez Magner J.A., Ksander B.R., Dubovy S.R.
Uveal melanoma cell lines: where do they come from? (an American Ophthalmological Society thesis).
Trans. Am. Ophthalmol. Soc. 114:T5-T5(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C307
Cell_Model_Passport; SIDM01843
DepMap; ACH-002018
Encyclopedic resources Wikidata; Q54936373
Polymorphism and mutation databases Cosmic; 916146
Cosmic; 1628398
Entry history
Entry creation22-Oct-2012
Last entry update10-Sep-2024
Version number20