Cellosaurus logo
expasy logo

Cellosaurus Mel202 (CVCL_C301)

[Text version]
Cell line name Mel202
Synonyms MEL202; Mel-202; Mel 202; mel-202; EST128
Accession CVCL_C301
Resource Identification Initiative To cite this cell line use: Mel202 (RRID:CVCL_C301)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 43 hours (PubMed=24994677).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Leu65Argfs*52 (c.194_201del) (p.Pro80fs, c.237_244del); Zygosity=Unspecified (PubMed=23851445).
  • Mutation; HGNC; 4390; GNAQ; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000375955; Zygosity=Unspecified (PubMed=22236444; PubMed=23851445; PubMed=28018010; DepMap=ACH-001554).
  • Mutation; HGNC; 4390; GNAQ; Simple; p.Arg210Lys (c.629G>A); Zygosity=Unspecified (PubMed=22236444; PubMed=23851445; PubMed=28018010; DepMap=ACH-001554).
  • Mutation; HGNC; 10768; SF3B1; Simple; p.Arg625Gly (c.1793C>T); ClinVar=VCV000376536; Zygosity=Unspecified (PubMed=24994677).
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001554; ECACC=13012457; ESTDAB=ESTDAB-128; PubMed=22236444; PubMed=24994677

Markers:
AmelogeninX
CSF1PO10,11
D3S135816
D5S81811,12
D7S82011,12
D8S117913,16
D13S31711,13
D16S53911,12
D18S5112,15
D21S1130.2,31.2
FGA23,24
Penta D10,11
Penta E7,13
TH016 (ECACC=13012457)
6,7 (DepMap=ACH-001554; ESTDAB=ESTDAB-128; PubMed=22236444; PubMed=24994677)
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=1748551
Ksander B.R., Rubsamen P.E., Olsen K.R., Cousins S.W., Streilein J.W.
Studies of tumor-infiltrating lymphocytes from a human choroidal melanoma.
Invest. Ophthalmol. Vis. Sci. 32:3198-3208(1991)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394
Griewank K.G., Yu X.-X., Khalili J.S., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676
Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V., Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M., Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.
A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.
Mol. Cancer Ther. 11:888-897(2012)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Amirouchene-Angelozzi N., Nemati F., Gentien D., Nicolas A., Dumont A., Carita G., Camonis J., Desjardins L., Cassoux N., Piperno-Neumann S., Mariani P., Sastre-Garau X., Decaudin D., Roman-Roman S.
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

PubMed=28018010; PMCID=PMC5161001
Jager M.J., Bermudez Magner J.A., Ksander B.R., Dubovy S.R.
Uveal melanoma cell lines: where do they come from? (an American Ophthalmological Society thesis).
Trans. Am. Ophthalmol. Soc. 114:T5-T5(2016)

Cross-references
Cell line collections (Providers) ECACC; 13012457
Kerafast; EEE003
Cell line databases/resources cancercelllines; CVCL_C301
Cell_Model_Passport; SIDM01357
DepMap; ACH-001554
ESTDAB; ESTDAB-128
Encyclopedic resources Wikidata; Q54905161
Experimental variables resources EFO; EFO_0022364
Gene expression databases GEO; GSM156005
Polymorphism and mutation databases Cosmic; 848329
Cosmic; 899894
Cosmic; 916143
Cosmic; 1047643
Cosmic; 1320372
Cosmic; 1628395
Cosmic; 2036706
Cosmic; 2163830
IARC_TP53; 26116
Progenetix; CVCL_C301
Entry history
Entry creation22-Oct-2012
Last entry update10-Sep-2024
Version number29