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Cellosaurus NCC-CCS1-X4-C1 (CVCL_B3TR)

[Text version]
Cell line name NCC-CCS1-X4-C1
Synonyms NCCCCS1X4C1
Accession CVCL_B3TR
Resource Identification Initiative To cite this cell line use: NCC-CCS1-X4-C1 (RRID:CVCL_B3TR)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCC sarcoma cell line panel.
Population: Japanese.
Characteristics: Established from a fourth generation xenograft established by subcutaneous injection in female NOD/Shi-scid IL-2Rgammanull mice.
Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo, Tadashi).
Doubling time: 17 hours (PubMed=29197033).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Left thigh, hypodermis; UBERON=UBERON_0000376+UBERON_0002072.
Sequence variations
  • Gene fusion; HGNC; 783; ATF1 + HGNC; 3508; EWSR1; Name(s)=EWSR1-ATF1, EWS-ATF (PubMed=29197033).
Disease Clear cell sarcoma of soft tissue (NCIt: C3745)
Soft tissue sarcoma (ORDO: Orphanet_3394)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_B3TS ! NCC-CCS1B-C1
CVCL_B3TT ! NCC-CCS1B-X2-C1
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): PubMed=29197033; PubMed=36959380

Markers:
AmelogeninX
CSF1PO10
D3S135817
D5S81811
D7S82011,12
D8S117912,14
D13S3178
D16S53911
D18S5116,19
D21S1130,31 (PubMed=29197033)
31 (PubMed=36959380)
FGA23
Penta D12
Penta E12,19
TH016
TPOX11
vWA15,16

Run an STR similarity search on this cell line
Web pages https://en.cellline.jp/product/ncc-ccs1-x4-c1/
Publications

PubMed=29197033; DOI=10.1007/s11626-017-0207-5
Sakumoto M., Oyama R., Takahashi M., Takai Y., Kito F., Shiozawa K., Qiao Z.-W., Endo M., Yoshida A., Kawai A., Kondo T.
Establishment and proteomic characterization of patient-derived clear cell sarcoma xenografts and cell lines.
In Vitro Cell. Dev. Biol. Anim. 54:163-176(2018)

PubMed=36959380; DOI=10.1038/s41416-023-02222-0; PMCID=PMC10147623
Rasmussen S.V., Wozniak A., Lathara M., Goldenberg J.M., Samudio B.M., Bickford L.R., Nagamori K., Wright H., Woods A.D., Chauhan S., Lee C.-J., Rudzinski E.R., Swift M.K., Kondo T., Fisher D.E., Imyanitov E.N., Machado I., Llombart-Bosch A., Andrulis I.L., Gokgoz N., Wunder J.S., Moritake H., Nakamura T., Srinivasa G., Thway K., Jones R.L., Huang P.H., Berlow N.E., Schoffski P., Keller C.
Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma.
Br. J. Cancer 128:1941-1954(2023)

Cross-references
Cell line databases/resources DepMap; ACH-002793
Encyclopedic resources Wikidata; Q110433080
Sequence databases EGA; EGAD00001008611
Entry history
Entry creation16-Dec-2021
Last entry update10-Sep-2024
Version number6