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Cellosaurus Z-138 (CVCL_B077)

[Text version]
Cell line name Z-138
Synonyms Z138
Accession CVCL_B077
Resource Identification Initiative To cite this cell line use: Z-138 (RRID:CVCL_B077)
Comments Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).
Population: Caucasian.
Doubling time: 24 hours (PubMed=25315077).
Omics: Array-based CGH.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: HLA*C loci for PubMed=24362935 was incorrect, modified version submitted by Pellat-Deceunynck, Catherine.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 12032; TRAF2; Simple; p.Trp114Ter (c.341G>A); Zygosity=Unspecified (PubMed=24362935).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01,23:01
HLA-BB*08:01,44:05
HLA-CC*02:02,07:06
Class II
HLA-DQDQA1*05:01,01:01
DQB1*05:01,02:01
HLA-DRDRB1*03:01,01:01

Source: PubMed=25688540
Class I
HLA-AA*01,23
HLA-BB*08,44
HLA-CC*02,07
Disease Mantle cell lymphoma (NCIt: C4337)
Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3001; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133819
D3S135816
D5S81811,13
D7S8208
D8S11798,13
D13S3179,12
D16S53911
D18S5114,18
D19S43312,14
D21S1130,32.2
FGA20,22
Penta D13,15
Penta E7,18
TH016
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=9669839; DOI=10.1016/S0145-2126(97)00191-4
Estrov Z., Talpaz M., Ku S., Harris D., Van Q., Beran M., Hirsch-Ginsberg C.F., Huh Y.O., Yee G., Kurzrock R.
Z-138: a new mature B-cell acute lymphoblastic leukemia cell line from a patient with transformed chronic lymphocytic leukemia.
Leuk. Res. 22:341-353(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16183118; DOI=10.1016/j.leukres.2005.08.016
Tucker C.A., Bebb G., Klasa R.J., Chhanabhai M., Lestou V.S., Horsman D.E., Gascoyne R.D., Wiestner A., Masin D., Bally M., Williams M.E.
Four human t(11;14)(q13;q32)-containing cell lines having classic and variant features of mantle cell lymphoma.
Leuk. Res. 30:449-457(2006)

PubMed=16203034; DOI=10.1016/j.leukres.2005.08.026
Medeiros L.J., Estrov Z., Rassidakis G.Z.
Z-138 cell line was derived from a patient with blastoid variant mantle cell lymphoma.
Leuk. Res. 30:497-501(2006)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731
Beltran E., Fresquet V., Martinez-Useros J., Richter-Larrea J.A., Sagardoy A., Sesma I., Almada L.L., Montes-Moreno S., Siebert R., Gesk S., Calasanz M.J., Malumbres R., Rieger M., Prosper F., Lossos I.S., Piris M.A., Fernandez-Zapico M.E., Martinez-Climent J.A.
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

PubMed=24362935; DOI=10.1038/nm.3435
Rahal R., Frick M., Romero R., Korn J.M., Kridel R., Chan F.C., Meissner B., Bhang H.-E.C., Ruddy D., Kauffmann A., Farsidjani A., Derti A., Rakiec D., Naylor T., Pfister E., Kovats S., Kim S., Dietze K., Dorken B., Steidl C., Tzankov A., Hummel M., Monahan J.E., Morrissey M.P., Fritsch C., Sellers W.R., Cooke V.G., Gascoyne R.D., Lenz G., Stegmeier F.
Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma.
Nat. Med. 20:87-92(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25315077; DOI=10.3109/10428194.2014.970548
Fogli L.K., Williams M.E., Connors J.M., Reid Y.A., Brown K., O'Connor O.A.
Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.
Leuk. Lymphoma 56:2114-2122(2015)

PubMed=25688540; DOI=10.1002/cyto.a.22643
Maiga S., Brosseau C., Descamps G., Dousset C., Gomez-Bougie P., Chiron D., Menoret E., Kervoelen C., Vie H., Cesbron A., Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
Cytometry A 87:285-288(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26194763; DOI=10.1182/blood-2015-01-624585; PMCID=PMC4582332
Bhatt S., Matthews J., Parvin S., Sarosiek K.A., Zhao D.-K., Jiang X.-Y., Isik E., Letai A.G., Lossos I.S.
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
Blood 126:1555-1564(2015)

PubMed=27697772; DOI=10.1182/blood-2016-06-720490
Chiron D., Bellanger C., Papin A., Tessoulin B., Dousset C., Maiga S., Moreau A., Esbelin J., Trichet V., Chen-Kiang S., Moreau P., Touzeau C., Le Gouill S., Amiot M., Pellat-Deceunynck C.
Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma.
Blood 128:2808-2818(2016)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Pham L.V., Huang S.-J., Zhang H., Zhang J., Bell T., Zhou S.-H., Pogue E., Ding Z.-Y., Lam L., Westin J., Davis R.E., Young K.H., Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

Cross-references
Cell line collections (Providers) ATCC; CRL-3001
Cell line databases/resources cancercelllines; CVCL_B077
Lonza; 1605
Biological sample resources BioSample; SAMN03471023
Chemistry resources ChEMBL-Cells; CHEMBL4483125
ChEMBL-Targets; CHEMBL4483276
PubChem_Cell_line; CVCL_B077
Encyclopedic resources Wikidata; Q54995848
Experimental variables resources EFO; EFO_0005479
Gene expression databases GEO; GSM115807
GEO; GSM629502
GEO; GSM629503
GEO; GSM1044974
GEO; GSM1044975
GEO; GSM1044976
GEO; GSM1044977
GEO; GSM1266779
GEO; GSM1266780
GEO; GSM1266787
GEO; GSM1266788
GEO; GSM1266789
GEO; GSM1266790
GEO; GSM1266791
GEO; GSM1266792
GEO; GSM2322624
Polymorphism and mutation databases Cosmic; 2078183
Cosmic; 2088021
Cosmic; 2296992
Cosmic; 2756238
Progenetix; CVCL_B077
Entry history
Entry creation06-Jun-2012
Last entry update10-Sep-2024
Version number29