Cellosaurus logo
expasy logo

Cellosaurus Jurkat/A4 (CVCL_AR84)

[Text version]
Cell line name Jurkat/A4
Synonyms Jurkat-A4
Accession CVCL_AR84
Resource Identification Initiative To cite this cell line use: Jurkat/A4 (RRID:CVCL_AR84)
Comments Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

CLPUB00316
Sokolovskaya A.A., Zabotina T.N., Blokhin D.Y., Inshakov A.N., Mikhailov A.D., Kadagidze Z.G., Baryshnikov A.Y.
CD95-deficient cells of Jurkat/A4 subline are resistant to drug-induced apoptosis.
Exp. Oncol. 23:175-180(2001)

PubMed=20693966
Philchenkov A.A., Zavelevych M., Savinska L., Blokhin D.Y.
Jurkat/A4 cells with multidrug resistance exhibit reduced sensitivity to quercetin.
Exp. Oncol. 32:76-80(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AR84
Encyclopedic resources Wikidata; Q54899163
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number16