ID   U937/EVI1
AC   CVCL_A5ZK
DR   cancercelllines; CVCL_A5ZK
DR   Wikidata; Q107117183
RX   PubMed=21394097;
CC   Population: Caucasian.
CC   Characteristics: Transduced with a MECOM/EVI1-IRES-EGFP construct.
CC   Sequence variation: Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; 3498; MECOM.
CC   Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 10-09-24; Version: 7
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RX   PubMed=21394097; DOI=10.1038/leu.2011.36;
RA   Saito Y., Nakahata S., Yamakawa N., Kaneda K., Ichihara E.,
RA   Suekane A., Morishita K.;
RT   "CD52 as a molecular target for immunotherapy to treat acute myeloid
RT   leukemia with high EVI1 expression.";
RL   Leukemia 25:921-931(2011).
//