ID   U937-ASPI3K
AC   CVCL_A5BW
DR   cancercelllines; CVCL_A5BW
DR   Wikidata; Q107117182
RX   PubMed=12578639;
RX   PubMed=12840909;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 795; ATM (Note=In antisense orientation).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 10-09-24; Version: 8
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RX   PubMed=12578639;
RA   Zhou J.-F., Liu W.-L., Tang Y., Dai Q.-L., Sun L.;
RT   "Establishment of the cell line U937-ASPI3K with stable expression of
RT   antisense ATM/PI3K.";
RL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 9:22-25(2001).
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RX   PubMed=12840909; DOI=10.1007/BF02888177;
RA   Zhou J.-F., Liu W.-L., Sun L., Sun H.-Y., Tang Y.;
RT   "Multiple defects of cell cycle checkpoints in U937-ASPI3K, an U937
RT   cell mutant stably expressing anti-sense ATM gene cDNA.";
RL   J. Tongji Med. Univ. 20:273-276(2000).
//