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Cellosaurus HSC-39 (CVCL_A385)

[Text version]
Cell line name HSC-39
Synonyms HSC39
Accession CVCL_A385
Resource Identification Initiative To cite this cell line use: HSC-39 (RRID:CVCL_A385)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 28-30 hours (PubMed=1846312).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Homozygous (PubMed=11107048; Cosmic-CLP=1322224; DepMap=ACH-002141).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.43
Native American0
East Asian, North78.69
East Asian, South18.67
South Asian0.72
European, North1.03
European, South0.47
Disease Gastric signet ring cell adenocarcinoma (NCIt: C5250)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C7UP (39As8)CVCL_D5HX (HSC-39 PF)
Originate from same individual CVCL_A386 ! HSC-40A
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1322224; JCRB=JCRB1864

Markers:
AmelogeninX
CSF1PO11
D5S81813 (Cosmic-CLP=1322224)
13,14 (JCRB=JCRB1864)
D7S82011,12 (JCRB=JCRB1864)
12 (Cosmic-CLP=1322224)
D13S3179
D16S5399
TH017,9
TPOX8
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=1846312
Yanagihara K., Seyama T., Tsumuraya M., Kamada N., Yokoro K.
Establishment and characterization of human signet ring cell gastric carcinoma cell lines with amplification of the c-myc oncogene.
Cancer Res. 51:381-386(1991)

PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x
Yokozaki H.
Molecular characteristics of eight gastric cancer cell lines established in Japan.
Pathol. Int. 50:767-777(2000)

PubMed=11543663; DOI=10.1006/viro.2001.1071
Fukuda M., Ikuta K., Yanagihara K., Tajima M., Kuratsune H., Kurata T., Sairenji T.
Effect of transforming growth factor-beta1 on the cell growth and Epstein-Barr virus reactivation in EBV-infected epithelial cell lines.
Virology 288:109-118(2001)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020
Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=26934957; DOI=10.1038/srep22371; PMCID=PMC4776110
Kurashige J., Hasegawa T., Niida A., Sugimachi K., Deng N., Mima K., Uchi R., Sawada G., Takahashi Y., Eguchi H., Inomata M., Kitano S., Fukagawa T., Sasako M., Sasaki H., Sasaki S., Mori M., Yanagihara K., Baba H., Miyano S., Tan P., Mimori K.
Integrated molecular profiling of human gastric cancer identifies DDR2 as a potential regulator of peritoneal dissemination.
Sci. Rep. 6:22371-22371(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB1864
Cell line databases/resources cancercelllines; CVCL_A385
Cell_Model_Passport; SIDM00045
CGH-DB; 106-1
CGH-DB; 9001-4
Cosmic-CLP; 1322224
DepMap; ACH-002141
CRISP screens repositories BioGRID_ORCS_Cell_line; 891
Chemistry resources GDSC; 1322224
PharmacoDB; HSC39_621_2019
Encyclopedic resources Wikidata; Q54896389
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669905
Polymorphism and mutation databases Cosmic; 875904
Cosmic; 876557
Cosmic; 877037
Cosmic; 897522
Cosmic; 922691
Cosmic; 926116
Cosmic; 1223584
Cosmic; 1460703
Cosmic; 1518248
Cosmic; 1571763
IARC_TP53; 13724
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number29