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Cellosaurus 92-1 [Human uveal melanoma] (CVCL_8607)

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Cell line name 92-1 [Human uveal melanoma]
Synonyms 92_1; 92.1; 921
Accession CVCL_8607
Resource Identification Initiative To cite this cell line use: 92-1 [Human uveal melanoma] (RRID:CVCL_8607)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 58 hours (PubMed=7622289); 38 hours (PubMed=24994677).
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Sequence variations
HLA typing Source: PubMed=28018010
Class I
HLA-AA*02:01,03:01
HLA-BB*44:02,51:01
HLA-CC*05:01,14:02
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C4PP (92.1-A)CVCL_C4PQ (92.1-B)
Originate from same individual CVCL_C300 ! 92-2
Sex of cell Female
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001441; ECACC=13012458; ESTDAB=ESTDAB-127; PubMed=22236444; PubMed=24994677; PubMed=28018010

Markers:
AmelogeninX
CSF1PO10,11
D3S135814,15
D5S8189,11 (DepMap=ACH-001441; ECACC=13012458; PubMed=22236444; PubMed=24994677)
12,13 (ESTDAB=ESTDAB-127)
D7S82010,11 (DepMap=ACH-001441; ECACC=13012458; PubMed=22236444; PubMed=24994677)
11 (ESTDAB=ESTDAB-127)
D8S117915
D13S31710,11 (ESTDAB=ESTDAB-127; PubMed=24994677)
11,12 (DepMap=ACH-001441; ECACC=13012458; PubMed=22236444)
D16S53911,12 (PubMed=22236444; PubMed=24994677)
12 (DepMap=ACH-001441; ECACC=13012458)
D18S5112,13
D21S1130
FGA21,23
Penta D9,11
Penta E12,14
TH019,9.3
TPOX8,9
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=7622289; DOI=10.1002/ijc.2910620208
De Waard-Siebinga I., Blom D.-J.R., Griffioen M., Schrier P.I., Hoogendoorn E., Beverstock G.C., Danen E.H.J., Jager M.J.
Establishment and characterization of an uveal-melanoma cell line.
Int. J. Cancer 62:155-161(1995)

PubMed=15714118; DOI=10.1097/00008390-200502000-00006
Lopez-Velasco R., Morilla-Grasa A., Saornil-Alvarez M.A., Ordonez J.L., Blanco G., Rabano G., Fernandez N., Almaraz A.
Efficacy of five human melanocytic cell lines in experimental rabbit choroidal melanoma.
Melanoma Res. 15:29-37(2005)

PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016
White J.S., Becker R.L., McLean I.W., Director-Myska A.E., Nath J.
Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.
Cancer Genet. Cytogenet. 168:11-21(2006)

PubMed=17487557; DOI=10.1007/s10585-007-9072-z
Marshall J.-C., Nantel A., Blanco P., Ash J., Cruess S.R., Burnier M.N. Jr.
Transcriptional profiling of human uveal melanoma from cell lines to intraocular tumors to metastasis.
Clin. Exp. Metastasis 24:353-362(2007)

PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131
Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello Osuna F., Garrido F., Garcia-Lora A.
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394
Griewank K.G., Yu X.-X., Khalili J.S., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676
Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V., Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M., Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.
A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.
Mol. Cancer Ther. 11:888-897(2012)

PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011
Amaro A., Mirisola V., Angelini G., Musso A., Tosetti F.I., Esposito A.I., Perri P., Lanza F.B., Nasciuti F., Mosci C., Puzone R., Salvi S., Truini M., Poggi A., Pfeffer U.
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.
Eur. J. Cancer 49:3353-3365(2013)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Amirouchene-Angelozzi N., Nemati F., Gentien D., Nicolas A., Dumont A., Carita G., Camonis J., Desjardins L., Cassoux N., Piperno-Neumann S., Mariani P., Sastre-Garau X., Decaudin D., Roman-Roman S.
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

PubMed=28018010; PMCID=PMC5161001
Jager M.J., Bermudez Magner J.A., Ksander B.R., Dubovy S.R.
Uveal melanoma cell lines: where do they come from? (an American Ophthalmological Society thesis).
Trans. Am. Ophthalmol. Soc. 114:T5-T5(2016)

PubMed=32430489; DOI=10.1158/1535-7163.MCT-19-1016; PMCID=PMC7415561
Teh J.L.F., Purwin T.J., Han A., Chua V., Patel P., Baqai U., Liao C., Bechtel N., Sato T., Davies M.A., Aguirre-Ghiso J.A., Aplin A.E.
Metabolic adaptations to MEK and CDK4/6 cotargeting in uveal melanoma.
Mol. Cancer Ther. 19:1719-1726(2020)

PubMed=36164296; DOI=10.1016/j.dib.2022.108592; PMCID=PMC9508510
Fei X.-F., Xie X.-T., Ji X.-Y., Tian H.-Y., Sun F., Jiang D.-Y., Wang Z.-M., Huang Q.
Quantitative proteomic dataset of whole protein in three melanoma samples of 92.1, 92.1-A and 92.1-B.
Data Brief 45:108592.1-108592.7(2022)

Cross-references
Cell line collections (Providers) ECACC; 13012458
ICLC; HTL12001
Cell line databases/resources CLDB; cl7221
cancercelllines; CVCL_8607
DepMap; ACH-001441
ESTDAB; ESTDAB-127
Encyclopedic resources Wikidata; Q54605663
Experimental variables resources EFO; EFO_0022503
Gene expression databases GEO; GSM276761
Polymorphism and mutation databases Cosmic; 848328
Cosmic; 899893
Cosmic; 916137
Cosmic; 986619
Cosmic; 1320371
Cosmic; 1628394
Cosmic; 1669117
Cosmic; 2036703
Cosmic; 2163829
Proteomic databases PRIDE; PXD032215
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number36