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Cellosaurus UW228 (CVCL_8585)

[Text version]
Cell line name UW228
Synonyms UW 228; HBT 228; HBT228
Accession CVCL_8585
Resource Identification Initiative To cite this cell line use: UW228 (RRID:CVCL_8585)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Deep exome analysis.
Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Thr155Asn (c.464C>A); ClinVar=VCV000406564; Zygosity=Unspecified (PubMed=18505928; DepMap=ACH-001232).
Disease Medulloblastoma, SHH-activated, TP53-mutant (NCIt: C129442)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4460 (UW228-1)CVCL_0572 (UW228-2)CVCL_0573 (UW228-3)
Originate from same individual CVCL_DH81 ! UW402
CVCL_DH82 ! UW426
Sex of cell Female
Age at sampling 9Y
Category Cancer cell line
Publications

DOI=10.1007/0-306-46861-1_11
Ali-Osman F.
Brain tumors.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

PubMed=10667577
Srivenugopal K.S., Mullapudi S.R.S., Shou J., Hazra T.K., Ali-Osman F.
Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells.
Cancer Res. 60:282-287(2000)

PubMed=11023825; DOI=10.1042/bj3510393; PMCID=PMC1221375
Mullapudi S.R.S., Ali-Osman F., Shou J., Srivenugopal K.S.
DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
Biochem. J. 351:393-402(2000)

PubMed=18505928; DOI=10.1158/1541-7786.MCR-07-2105; PMCID=PMC2570202
Lo H.-W., Stephenson L., Cao X.-Y., Milas M., Pollock R.E., Ali-Osman F.
Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.
Mol. Cancer Res. 6:843-850(2008)

PubMed=20847082; DOI=10.1093/neuonc/noq091; PMCID=PMC3018940
Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y.-F., Marquez V.E., Cho Y.-J., Pomeroy S.L.
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=21177782; DOI=10.1093/neuonc/noq179; PMCID=PMC3064629
Weeraratne S.D., Amani V.M., Neiss A., Teider N., Scott D.K., Pomeroy S.L., Cho Y.-J.
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.
Neuro-oncol. 13:165-175(2011)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281; PMCID=PMC4198154
Bandopadhayay P., Bergthold G., Nguyen B., Schubert S., Gholamin S., Tang Y.-J., Bolin S., Schumacher S.E., Zeid R., Masoud S., Yu F.-R., Vue N., Gibson W.J., Paolella B.R., Mitra S.S., Cheshier S.H., Qi J., Liu K.-W., Wechsler-Reya R.J., Weiss W.A., Swartling F.J., Kieran M.W., Bradner J.E., Beroukhim R., Cho Y.-J.
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin. Cancer Res. 20:912-925(2014)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004; PMCID=PMC5079239
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8585
Cell_Model_Passport; SIDM01399
DepMap; ACH-001232
Encyclopedic resources Wikidata; Q54992372
Gene expression databases GEO; GSM919366
Polymorphism and mutation databases IARC_TP53; 26932
Progenetix; CVCL_8585
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number23