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Cellosaurus KMCH-1 (CVCL_7970)

[Text version]
Cell line name KMCH-1
Synonyms KMCH1; KMCH
Accession CVCL_7970
Resource Identification Initiative To cite this cell line use: KMCH-1 (RRID:CVCL_7970)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: ~39 hours (PubMed=3032760).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; p.Tyr346Cys (c.1037A>G); ClinVar=VCV000480380; Zygosity=Unspecified (DepMap=ACH-001853).
HLA typing Source: PubMed=9178645
Class I
HLA-AA*11:01,31:01
HLA-BB*51:01
HLA-CC*14:02
Class II
HLA-DRDRB1*08:02
Disease Combined hepatocellular carcinoma and cholangiocarcinoma (NCIt: C3828)
Combined hepatocellular carcinoma and cholangiocarcinoma (ORDO: Orphanet_529852)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001853

Markers:
AmelogeninX
CSF1PO12
D3S135815
D5S81812,13
D7S82010,12
D8S117910,14
D13S31711
D16S53910
D18S5113
D21S1129
FGA22
Penta D9
Penta E11,18
TH019.3
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=3032760; DOI=10.1002/hep.1840070322
Murakami T., Yano H., Maruiwa M., Sugihara S., Kojiro M.
Establishment and characterization of a human combined hepatocholangiocarcinoma cell line and its heterologous transplantation in nude mice.
Hepatology 7:551-556(1987)

PubMed=7537711; DOI=10.1002/hep.1840210510
Haramaki M., Yano H., Fukuda K., Momosaki S., Ogasawara S., Kojiro M.
Expression of CD44 in human hepatocellular carcinoma cell lines.
Hepatology 21:1276-1284(1995)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Nakao M., Sata M., Saitsu H., Yutani S., Kawamoto M., Kojiro M., Itoh K.
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=10347112; DOI=10.1002/hep.510290624
Yano H., Iemura A., Haramaki M., Ogasawara S., Takayama A., Akiba J., Kojiro M.
Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines.
Hepatology 29:1708-1717(1999)

CLPUB00275
Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451
Scherer D., Davila-Lopez M., Goeppert B., Abrahamsson S., Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D., Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Cancers (Basel) 12:2510.1-2510.14(2020)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y., Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S., Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7970
Cell_Model_Passport; SIDM01800
DepMap; ACH-001853
Anatomy/cell type resources BTO; BTO:0003310
Encyclopedic resources Wikidata; Q54900108
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number22