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Cellosaurus ACC-2 (CVCL_6872)

[Text version]
Cell line name ACC-2
Synonyms Acc-2; ACC2
Accession CVCL_6872
Resource Identification Initiative To cite this cell line use: ACC-2 (RRID:CVCL_6872)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=19557180; PubMed=20143388; PubMed=21868764; PubMed=26116706). Originally thought to originate from a 28 year old female patient with a salivary gland adenoid cystic carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00357.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Miscellaneous: Formerly the CCRID database had 3 entries describing this cell line (3111C0001CCC000272, 3131C0001000700062, 3142C0001000000048). They were one of the sources for the STR profile of this entry.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_6874 (ACC-M)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=21868764; PubMed=26116706

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135815,18
D5S81811,12
D7S8208,12
D8S117912,13
D13S31712,13.3
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
FGA21
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18 (PubMed=21868764; PubMed=26116706)
17,18 (CCRID)

Run an STR similarity search on this cell line
Web pages Info; ACCRF; -; https://web.archive.org/web/20110617125837/http://www.accrf.org/pdf/accrf_update_march2009.pdf
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=15495191; DOI=10.1002/gcc.20119
Sascha Raschke, Vera Balz, Thomas Efferth, Wolfgang A. Schulz, Andrea R. Florl;
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
Genes Chromosomes Cancer 42:58-67(2005)

PubMed=19557180; DOI=10.1371/journal.pone.0006040; PMCID=PMC2698276
Janyaporn Phuchareon, Yoshihito Ohta, Jonathan M. Woo, David William Eisele, Osamu Tetsu;
Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2.
PLoS ONE 4:e6040.1-e6040.8(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26116706; DOI=10.1096/fj.14-266718
Fang Ye, Chu-Guang Chen, Jian Qin, Jie Liu, Cong-Yi Zheng;
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

DOI=10.4103/2468-5585.200513
Nan-Nan Liu, Sen-Lin Zhang, Wei Chen;
The cross-contaminated cell lines of adenoid cystic carcinoma: a crucial concern.
Transl. Surg. 2:10-13(2017)

Cross-references
Cell line collections (Providers) CCTCC; GDC0048
Biological sample resources BioSample; SAMN03151659
Encyclopedic resources Wikidata; Q54608098
Polymorphism and mutation databases Cosmic; 932295
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29