Cellosaurus 451Lu (CVCL_6357)
Cell line name | 451Lu | ||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Synonyms | 451LU; 451-LU; WM 451-Lu; WM-451Lu; WM-451LU; WM451Lu; WM451; WC00059; LU451; Lu451; EST81 | ||||||||||||||||||||||||||||||||
Accession | CVCL_6357 | ||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: 451Lu (RRID:CVCL_6357) | ||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Part of: Wistar Institute melanoma cell line collection. Population: Caucasian. Characteristics: Metastatic. Established from the lung of a nude mouse after 4 sequential passages of the parent cell line (PubMed=2156614). Doubling time: 72 hours (PubMed=2253310). Microsatellite instability: Stable (MSS) (PubMed=31068700; Sanger). Omics: Array-based CGH. Omics: Deep exome analysis. Omics: Deep quantitative proteome analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: CSF1PO: 11,12->12, D18S51: 10->10,13, D5S818: 11,12->12, D7S820: 9,10->10 and FGA: 21->21,25. Derived from site: Metastatic; Arm, skin; UBERON=UBERON_0002427. | ||||||||||||||||||||||||||||||||
Sequence variations |
| ||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=15592718
| ||||||||||||||||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
| ||||||||||||||||||||||||||||||||
Disease | Cutaneous melanoma (NCIt: C3510) | ||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||
Hierarchy | Parent: CVCL_7928 (WM164) Children:
| ||||||||||||||||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||||||||||||||||
Age at sampling | 22Y | ||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||
STR profile | Source(s): ATCC=CRL-2813; Cosmic-CLP=1287706; ESTDAB=ESTDAB-081; PubMed=25056119; Wistar Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
Web pages | https://www.wistar.org/our-scientists/meenhard-herlyn | ||||||||||||||||||||||||||||||||
Publications | PubMed=2918552; DOI=10.1093/jnci/81.6.440 PubMed=2156614 PubMed=2253310; DOI=10.1007/BF00046337 PubMed=2068080; DOI=10.1073/pnas.88.14.6028; PMCID=PMC52015 PubMed=8342600; PMCID=PMC1887031 PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966 PubMed=17260012; DOI=10.1038/sj.onc.1210252 PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235; PMCID=PMC2615688 PubMed=18790768; DOI=10.1158/1535-7163.MCT-08-0431; PMCID=PMC2651569 PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131 PubMed=21156289; DOI=10.1016/j.ccr.2010.11.023; PMCID=PMC3026446 PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958; PMCID=PMC3070783 PubMed=23285177; DOI=10.1371/journal.pone.0052760; PMCID=PMC3532357 PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006 PubMed=24055054; DOI=10.1016/j.celrep.2013.08.023; PMCID=PMC3956616 PubMed=25056119; DOI=10.1158/0008-5472.CAN-14-1232-T; PMCID=PMC4167745 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675 PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103 PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775 | ||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||
Cell line collections (Providers) | ATCC; CRL-2813 - Discontinued
Coriell; WC00059 - Discontinued Rockland; 451Lu-01-0001 | ||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0001373
cancercelllines; CVCL_6357 Cell_Model_Passport; SIDM01240 Cosmic-CLP; 1287706 DepMap; ACH-001002 ESTDAB; ESTDAB-081 | ||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0003710 | ||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03471798 | ||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL4802054
GDSC; 1287706 PharmacoDB; 451Lu_17_2019 PubChem_Cell_line; CVCL_6357 | ||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q54603178 | ||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-3610
GEO; GSM156019 GEO; GSM188238 GEO; GSM188268 GEO; GSM188327 GEO; GSM555137 GEO; GSM555187 GEO; GSM952579 GEO; GSM1199178 GEO; GSM1669568 | ||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 686411
Cosmic; 1047656 Cosmic; 1155281 Cosmic; 1155568 Cosmic; 1187587 Cosmic; 1303027 Cosmic; 2163808 Cosmic; 2230114 IARC_TP53; 26083 Progenetix; CVCL_6357 | ||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD030304 | ||||||||||||||||||||||||||||||||
Sequence databases | EGA; EGAS00001000978 | ||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||
Last entry update | 02-May-2024 | ||||||||||||||||||||||||||||||||
Version number | 39 |