ID   DRO
AC   CVCL_6286
SY   DRO-90-1; DRO 90-1; DRO90-1; DRO-90; RO 90-D-1; UCLA RO 90-D-1
DR   BioSample; SAMN03151608
DR   BioSample; SAMN03151609
DR   cancercelllines; CVCL_6286
DR   Cosmic; 886551
DR   Cosmic; 888278
DR   Cosmic; 913249
DR   Cosmic; 1155330
DR   Wikidata; Q54831419
RX   PubMed=8871538;
RX   PubMed=18713817;
RX   PubMed=20143388;
RX   PubMed=21868764;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a A-375 derivative (PubMed=18713817; PubMed=20143388; PubMed=21868764). Originally thought to originate from a thyroid gland anaplastic carcinoma.
CC   From: Juillard, Guy Jean-Felix; University of California, Los Angeles; Los Angeles; USA.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00188.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
ST   Source(s): PubMed=18713817; PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,14
ST   D16S539: 9
ST   D18S51: 12,17
ST   D21S11: 29,30
ST   D3S1358: 15,17
ST   D5S818: 12
ST   D7S820: 9
ST   D8S1179: 11,14
ST   FGA: 20,23
ST   TH01: 8
ST   TPOX: 8,10
ST   vWA: 16,17
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 30
//
RX   PubMed=8871538; DOI=10.1007/BF00128960;
RA   Boghaert, Erwin R.
RA   Ain, Kenneth B.
RA   Taylor, Kimberly D.
RA   Greenberg, Victoria L.
RA   Fowler, Carol
RA   Zimmer, Stephen G. Sr.
RT   "Quantitative and qualitative differences in growth, invasion and lung
RT   colonization of an anaplastic and a papillary human thyroid cancer
RT   cell line in vitro and in vivo.";
RL   Clin. Exp. Metastasis 14:440-450(1996).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao, Mei
RA   Sano, Daisuke
RA   Pickering, Curtis R.
RA   Jasser, Samar A.
RA   Henderson, Ying C.
RA   Clayman, Gary L.
RA   Sturgis, Erich M.
RA   Ow, Thomas J.
RA   Lotan, Reuben
RA   Carey, Thomas E.
RA   Sacks, Peter G.
RA   Grandis, Jennifer Rubin
RA   Sidransky, David
RA   Heldin, Nils-Erik
RA   Myers, Jeffrey N.
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569;
RA   Schweppe, Rebecca E.
RA   Klopper, Joshua Paul
RA   Korch, Christopher T.
RA   Pugazhenthi, Umarani
RA   Benezra, Miriam
RA   Knauf, Jeffrey A.
RA   Fagin, James Alexander
RA   Marlow, Laura A.
RA   Copland, John Alton 3rd
RA   Smallridge, Robert Christian
RA   Haugen, Bryan R.
RT   "Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer
RT   cell lines reveals cross-contamination resulting in cell line
RT   redundancy and misidentification.";
RL   J. Clin. Endocrinol. Metab. 93:4331-4341(2008).
//