Cellosaurus logo
expasy logo

Cellosaurus SK-RC-31 (CVCL_6186)

[Text version]
Cell line name SK-RC-31
Synonyms SK-RC 31; SK RC 31; SKRC-31; SKRC31
Accession CVCL_6186
Resource Identification Initiative To cite this cell line use: SK-RC-31 (RRID:CVCL_6186)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Population: Caucasian.
Doubling time: 120 hours (PubMed=25984343).
Miscellaneous: STR profile and sex of donor from MSKCC antibody and bioresource core facility.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.19
Native American0.01
East Asian, North7.38
East Asian, South0
South Asian3.18
European, North19.72
European, South66.52
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133823
D3S135817
D5S81811,13
D7S8208,13
D8S117912,16
D13S3179,11
D16S53910,12
D18S5120
D19S43313,14
D21S1129
FGA24
TH016,7
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Web pages https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-rc-m-metastatic-human-renal-cell-carcinoma-rcc-cell-line-collection
Publications

PubMed=2386958
Ebert T., Bander N.H., Finstad C.L., Ramsawak R.D., Old L.J.
Establishment and characterization of human renal cancer and normal kidney cell lines.
Cancer Res. 50:5531-5536(1990)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=27993170; DOI=10.1186/s12943-016-0565-8; PMCID=PMC5168717
Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C., Czarnecka A.M.
Choosing the right cell line for renal cell cancer research.
Mol. Cancer 15:83.1-83.15(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6186
Cell_Model_Passport; SIDM01839
DepMap; ACH-001194
Chemistry resources PharmacoDB; SKRC31_1413_2019
Encyclopedic resources Wikidata; Q54954573
Gene expression databases GEO; GSM374463
Polymorphism and mutation databases Progenetix; CVCL_6186
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number24