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Cellosaurus HLC-1 (CVCL_5529)

[Text version]
Cell line name HLC-1
Synonyms HLC1
Accession CVCL_5529
Resource Identification Initiative To cite this cell line use: HLC-1 (RRID:CVCL_5529)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: ~33 hours (Note=At 29th passage) (PubMed=140093).
Caution: Indicated by Riken to originate from Okabe T. but with no reference provided. Therefore it is not certain that HLC-1 from Riken and HLC-1 originating from Akagi T. and Kimoto T. (PubMed=140093) are identical.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Genome ancestry Source: PubMed=30894373

Origin% genome
African4.37
Native American0
East Asian, North90.08
East Asian, South3.53
South Asian0
European, North0
European, South2.02
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4Y14 (HLC-1-Luc)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): RCB=RCB0083

Markers:
AmelogeninX
CSF1PO7,12
D5S8189,10
D7S82011,13
D13S3178
D16S5399,12
TH017,9
TPOX12
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=140093; DOI=10.20772/cancersci1959.67.4_483
Akagi T., Kimoto T.
Establishment and characteristics of a human lung adenocarcinoma cell line.
Gann 67:483-492(1976)

PubMed=3986962; DOI=10.1093/carcin/6.4.549
Watatani M., Ikenaga M., Hatanaka T., Kinuta M., Takai S.-i., Mori T., Kondo S.
Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer xenografts in athymic nude mice.
Carcinogenesis 6:549-553(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210
Kasai F., Fukushima M., Miyagi Y., Nakamura Y.
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Hum. Cell 37:944-950(2024)

Cross-references
Cell line collections (Providers) RCB; RCB0083
Cell line databases/resources CLO; CLO_0050024
cancercelllines; CVCL_5529
Cell_Model_Passport; SIDM01805
DepMap; ACH-001088
Biological sample resources BioSample; SAMN03472335
Chemistry resources PharmacoDB; HLC1_547_2019
Encyclopedic resources Wikidata; Q54889842
Gene expression databases GEO; GSM784262
Polymorphism and mutation databases Cosmic; 1154601
Progenetix; CVCL_5529
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number24