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Cellosaurus VACO 4S (CVCL_5406)

[Text version]
Cell line name VACO 4S
Synonyms VACO-4S; VACO4S; Vaco4S
Accession CVCL_5406
Resource Identification Initiative To cite this cell line use: VACO 4S (RRID:CVCL_5406)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Doubling time: 30 hours (PubMed=6498841).
Microsatellite instability: Stable (MSS) (PubMed=24755471).
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Ser1355fs*18 (c.4062_4066delTTCTT); Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Trp524Cys (c.1572G>T); ClinVar=VCV002147050; Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; 11998; TP53; Simple; p.Asn239fs*1 (c.715_717AAC>T); Zygosity=Unspecified (PubMed=24755471).
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5405 ! VACO 4A
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=6498841
McBain J.A., Weese J.L., Meisner L.F., Wolberg W.H., Willson J.K.V.
Establishment and characterization of human colorectal cancer cell lines.
Cancer Res. 44:5813-5821(1984)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A., Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A., Orphanides G., French T., Wessels L.F.A.
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5406
ColonAtlas; VACO4S
Encyclopedic resources Wikidata; Q54992767
Gene expression databases GEO; GSM1346860
GEO; GSM1374982
Polymorphism and mutation databases Cosmic; 948849
Cosmic; 986023
Cosmic; 1043834
Cosmic; 2302024
Cosmic; 2760188
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number21