Cellosaurus logo
expasy logo

Cellosaurus HCC2429 (CVCL_5132)

[Text version]
Cell line name HCC2429
Synonyms HCC-2429; Hamon Cancer Center 2429
Accession CVCL_5132
Resource Identification Initiative To cite this cell line use: HCC2429 (RRID:CVCL_5132)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Misspelling: HCC-2425; PubMed=29348827; Note=In table of supplementary material.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Gene fusion; HGNC; 13575; BRD4 + HGNC; 29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT (PubMed=15994877; PubMed=29348827).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg267Gln (c.800G>A); ClinVar=VCV000127823; Zygosity=Homozygous (DepMap=ACH-000143).
Disease Lung non-small cell carcinoma (NCIt: C2926)
NUT carcinoma (NCIt: C45716)
NUT midline carcinoma (ORDO: Orphanet_443167)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_V989 ! HCC2429 BL
Sex of cell Female
Age at sampling 34Y
Category Cancer cell line
STR profile Source(s): PubMed=20679594

Markers:
AmelogeninX
CSF1PO10,13
D5S81812,14
D7S82010,11
D13S31711
D16S53911,13
TH016,9
TPOX8
vWA16

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=10944559; DOI=10.1093/jnci/92.16.1355
Dang T.P., Gazdar A.F., Virmani A.K., Sepetavec T., Hande K.R., Minna J.D., Roberts J.R., Carbone D.P.
Chromosome 19 translocation, overexpression of Notch3, and human lung cancer.
J. Natl. Cancer Inst. 92:1355-1357(2000)

PubMed=15994877; DOI=10.1136/jmg.2004.029686; PMCID=PMC1736105
Haruki N., Kawaguchi K.S., Eichenberger S., Massion P.P., Gonzalez A., Gazdar A.F., Minna J.D., Carbone D.P., Dang T.P.
Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro.
J. Med. Genet. 42:558-564(2005)

PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=24736545; DOI=10.1158/0008-5472.CAN-13-2658; PMCID=PMC4097982
Wang R.-R., Liu W., Helfer C.M., Bradner J.E., Hornick J.L., Janicki S.M., French C.A., You J.-X.
Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma.
Cancer Res. 74:3332-3343(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512
Stirnweiss A., Oommen J., Kotecha R.S., Kees U.R., Beesley A.H.
Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease.
Oncotarget 8:112313-112329(2017)

PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540
McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R., Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M., Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L., Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J., DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A.F., Gibbs R.A., Hwang T.H., Heymach J.V., Wistuba I.I., Coombes K.R., Williams N.S., Wheeler D.A., MacMillan J.B., DeBerardinis R.J., Roth M.G., Posner B.A., Minna J.D., Kim H.S., White M.A.
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Cell 173:864-878.e29(2018)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084
Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A., Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M., Aldige C.R., Wistuba I.I., Minna J.D.
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
J. Cell. Biochem. 121:3986-3999(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5132
Cell_Model_Passport; SIDM01601
DepMap; ACH-000143
IGRhCellID; HCC2429GEO
Biological sample resources BioSample; SAMN10989601
Encyclopedic resources Wikidata; Q54881655
Experimental variables resources EFO; EFO_0022526
Gene expression databases GEO; GSM171900
GEO; GSM171901
GEO; GSM253412
GEO; GSM434319
GEO; GSM794394
Polymorphism and mutation databases Cosmic; 903644
Cosmic; 1146931
Cosmic; 1340147
Cosmic; 1518099
Progenetix; CVCL_5132
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number24