• Mutation; HGNC; 11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=28515451).
  

PubMed=11579460; DOI=10.1002/gcc.1184
Scheil S., Bruderlein S., Liehr T., Starke H., Herms J., Schulte M., Moller P.
Genome-wide analysis of sixteen chordomas by comparative genomic hybridization and cytogenetics of the first human chordoma cell line, U-CH1.
Genes Chromosomes Cancer 32:203-211(2001)

PubMed=20461036; DOI=10.1097/BRS.0b013e3181c2a8b0; PMCID=PMC3769690
Yang C., Hornicek F.J., Wood K.B., Schwab J.H., Choy E., Iafrate A.J., Rosenberg A.E., Nielsen G.P., Xavier R.J., Mankin H.J., Duan Z.-F.
Characterization and analysis of human chordoma cell lines.
Spine 35:1257-1264(2010)

PubMed=21253487; DOI=10.1155/2010/630129; PMCID=PMC3022207
Bruderlein S., Sommer J.B., Meltzer P.S., Li S.-F., Osada T., Ng D., Moller P., Alcorta D.A., Kelley M.J.
Molecular characterization of putative chordoma cell lines.
Sarcoma 2010:630129.1-630129.14(2010)

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
von Witzleben A., Goerttler L.T., Marienfeld R., Barth H., Lechel A., Mellert K., Bohm M., Kornmann M., Mayer-Steinacker R., von Baer A., Schultheiss M., Flanagan A.M., Moller P., Bruderlein S., Barth T.F.E.
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416
Scheipl S., Barnard M., Cottone L., Jorgensen M., Drewry D.H., Zuercher W.J., Turlais F., Ye H.-T., Leite A.P., Smith J.A., Leithner A., Moller P., Bruderlein S., Guppy N., Amary F., Tirabosco R., Strauss S.J., Pillay N., Flanagan A.M.
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J. Pathol. 239:320-334(2016)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B., von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A., Schultheiss M., Wirtz C.R., Moller P., Mellert K.
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

PubMed=28606919; DOI=10.1158/1078-0432.CCR-17-0177; PMCID=PMC5581713
Chen H., Garbutt C.C., Spentzos D., Choy E., Hornicek F.J., Duan Z.-F.
Expression and therapeutic potential of SOX9 in chordoma.
Clin. Cancer Res. 23:5176-5186(2017)

PubMed=28835717; DOI=10.1038/s41598-017-10044-3; PMCID=PMC5569021
Bosotti R., Magnaghi P., Di Bella S., Cozzi L., Cusi C., Bozzi F., Beltrami N., Carapezza G., Ballinari D., Amboldi N., Lupi R., Somaschini A., Raddrizzani L., Salom B., Galvani A., Stacchiotti S., Tamborini E., Isacchi A.
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1.
Sci. Rep. 7:9226-9226(2017)