Cellosaurus logo
expasy logo

Cellosaurus RBE (CVCL_4896)

[Text version]
Cell line name RBE
Accession CVCL_4896
Resource Identification Initiative To cite this cell line use: RBE (RRID:CVCL_4896)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JFCR45 cancer cell line panel.
Population: Japanese.
Doubling time: 45 hours (PubMed=9358283).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Misspelling: RBA; CelloPub=CLPUB00275.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Ser (c.394C>A); ClinVar=VCV000375893; Zygosity=Unspecified (PubMed=27231123; DepMap=ACH-001856).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (DepMap=ACH-001856).
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A9CU (RBE-Luc2-tdT)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): CCRID; DepMap=ACH-001856; RCB=RCB1292

Markers:
AmelogeninX
CSF1PO12
D2S133817,24
D3S135814,15
D5S81811,12
D7S8208,11
D8S117913,14
D13S3179
D16S53910,11
D18S5113,15
D19S43314,15.2
D21S1129
FGA19,24
Penta D12
Penta E18
TH016
TPOX8
vWA20

Run an STR similarity search on this cell line
Web pages https://cell.brc.riken.jp/en/rcb/rbessp-25_announce
Publications

PubMed=9358283; DOI=10.1007/s11626-997-0125-z
Enjoji M., Sakai H., Nawata H., Kajiyama K., Tsuneyoshi M.
Sarcomatous and adenocarcinoma cell lines from the same nodule of cholangiocarcinoma.
In Vitro Cell. Dev. Biol. Anim. 33:681-683(1997)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

CLPUB00275
Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442; PMCID=PMC5458737
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X.-X., Joung J.K., Shokat K.M., Benes C.H., El-Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=31077409; DOI=10.1002/hep.30704
Sittithumcharee G., Suppramote O., Vaeteewoottacharn K., Sirisuksakun C., Jamnongsong S., Laphanuwat P., Suntiparpluacha M., Matha A., Chusorn P., Buraphat P., Kakanaporn C., Charngkaew K., Silsirivanit A., Korphaisarn K., Limsrichamrern S., Tripatara P., Pairojkul C., Wongkham S., Sampattavanich S., Okada S., Jirawatnotai S.
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Hepatology 70:1614-1630(2019)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y., Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S., Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

Cross-references
Cell line collections (Providers) CLS; 305019
KCB; KCB 2014049YJ
RCB; RCB1292
Cell line databases/resources CLO; CLO_0050848
cancercelllines; CVCL_4896
CCRID; 1101HUM-PUMC000675
CCRID; 3101HUMTCHu179
Cell_Model_Passport; SIDM01850
DepMap; ACH-001856
Biological sample resources BioSample; SAMN03472125
Encyclopedic resources Wikidata; Q54949330
Polymorphism and mutation databases Cosmic; 1187341
Cosmic; 1571785
Cosmic; 2629289
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number31