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Cellosaurus PWR-1E (CVCL_3775)

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Cell line name PWR-1E
Synonyms PWR1E
Accession CVCL_3775
Resource Identification Initiative To cite this cell line use: PWR-1E (RRID:CVCL_3775)
Comments Group: Patented cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11611.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: Ad12-SV40 hybrid virus.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Prostate, epithelium; UBERON=UBERON_0000428.
Cell type: Epithelial cell of prostate; CL=CL_0002231.
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.52
Native American0
East Asian, North2.82
East Asian, South0
South Asian0
European, North64.08
European, South30.58
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-11611; Cosmic-CLP=1330993

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81811,13
D7S8209,11
D13S31712
D16S53912,13
TH018,9.3
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=8761420; DOI=10.1093/carcin/17.8.1641
Mukta M. Webber, Diana Bello, Hynda Karen Kleinman, David Don Wartinger, Daniel E. Williams, Johng Sik Rhim;
Prostate specific antigen and androgen receptor induction and characterization of an immortalized adult human prostatic epithelial cell line.
Carcinogenesis 17:1641-1646(1996)

PubMed=8977636; DOI=10.1002/(SICI)1097-0045(199612)29:6<386::AID-PROS7>3.0.CO;2-6
Mukta M. Webber, Diana Bello, Salmaan T.A. Quader;
Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications. Part I. Cell markers and immortalized nontumorigenic cell lines.
Prostate 29:386-394(1996)

Patent=US5814452
Mukta M. Webber, Johng Sik Rhim;
Human prostatic cell lines immortalized by adenovirus 12-simian virus 40 (AD12/SV40) hybrid virus.
Patent number US5814452, 29-Sep-1998

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-11611 - Discontinued
Cell line databases/resources CLO; CLO_0008671
cancercelllines; CVCL_3775
Cell_Model_Passport; SIDM01114
Cosmic-CLP; 1330993
DepMap; ACH-001383
Anatomy/cell type resources BTO; BTO_0005178
Biological sample resources BioSample; SAMN03471342
Chemistry resources ChEMBL-Cells; CHEMBL4295467
ChEMBL-Targets; CHEMBL4296487
GDSC; 1330993
PharmacoDB; PWR1E_1279_2019
PubChem_Cell_line; CVCL_3775
Encyclopedic resources Wikidata; Q54948720
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827268
GEO; GSM1670354
Polymorphism and mutation databases Progenetix; CVCL_3775
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32