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Cellosaurus HMy2.C1R (CVCL_3714)

[Text version]
Cell line name HMy2.C1R
Synonyms Hmy.2 CIR; HMy2.CIR; C1R
Accession CVCL_3714
Secondary accession CVCL_E511
Resource Identification Initiative To cite this cell line use: HMy2.C1R (RRID:CVCL_3714)
Comments Part of: 12th International Histocompatibility Workshop (12IHW) cell line panel.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: NCIt; C44386; Gamma radiation.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
HLA typing Source: IPD-IMGT/HLA=10372
Class I
HLA-AA*02:01
HLA-BB*35:03
HLA-CC*04:01:01
Class II
HLA-DPDPB1*04:01,04:02
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8119 (HMy.2 B)
Children:
CVCL_C0R9 (C1R-A11)CVCL_9U98 (C1R-A2)CVCL_S990 (C1R-A24)
CVCL_S991 (C1R-A31)CVCL_C0RA (C1R-A33)CVCL_J349 (C1R-B27)
CVCL_C5VD (C1R-B*27:02)CVCL_C5VE (C1R-B*27:05)CVCL_6373 (C1R-B7)
CVCL_6374 (C1R-neo)CVCL_6375 (C1R-sB7)
Sex of cell Female
Age at sampling 33Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-1993

Markers:
AmelogeninX
CSF1PO6,10
D2S133817
D3S135816
D5S81810,13
D7S8207,12
D8S117915
D13S31711,13
D16S5399,13
D18S5114,16
D19S43314,15
D21S1129,30
FGA20,21
Penta D10
Penta E12
TH018
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-408.html
Publications

PubMed=3819393; DOI=10.4049/jimmunol.138.6.1657
Storkus W.J., Howell D.N., Salter R.D., Dawson J.R., Cresswell P.
NK susceptibility varies inversely with target cell class I HLA antigen expression.
J. Immunol. 138:1657-1659(1987)

PubMed=2784569; DOI=10.1073/pnas.86.7.2361; PMCID=PMC286912
Storkus W.J., Alexander J., Payne J.A., Dawson J.R., Cresswell P.
Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.
Proc. Natl. Acad. Sci. U.S.A. 86:2361-2364(1989)

PubMed=1541831; DOI=10.4049/jimmunol.148.6.1941
Zemmour J., Little A.-M., Schendel D.J., Parham P.
The HLA-A,B 'negative' mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon.
J. Immunol. 148:1941-1948(1992)

PubMed=30844424; DOI=10.1016/j.humimm.2019.03.001; PMCID=PMC6599558
Creary L.E., Guerra S.G., Chong W., Brown C.J., Turner T.R., Robinson J., Bultitude W.P., Mayor N.P., Marsh S.G.E., Saito K., Lam K., Duke J.L., Mosbruger T.L., Ferriola D., Monos D.S., Willis A., Askar M., Fischer G.F., Saw C.L., Ragoussis J., Petrek M., Serra-Pages C., Juan Otero M., Stavropoulos-Giokas C., Dinou A., Ameen R., Al Shemmari S., Spierings E., Gendzekhadze K., Morris G.P., Zhang Q.-H., Kashi Z., Hsu S., Gangavarapu S., Mallempati K.C., Yamamoto F., Osoegawa K., Vayntrub T., Chang C.-J., Hansen J.A., Fernandez-Vina M.A.
Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: report from the 17th International HLA and Immunogenetics Workshop.
Hum. Immunol. 80:449-460(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-1993
CLS; 305126
ECACC; 94050320
Cell line databases/resources CLO; CLO_0003787
CCRID; 3101HUMGNHu21
dbMHC; 48526
IHW; IHW09208
IPD-IMGT/HLA; 10372
Lonza; 1264
Anatomy/cell type resources BTO; BTO:0003699
Chemistry resources ChEMBL-Cells; CHEMBL4295449
ChEMBL-Targets; CHEMBL4296434
PubChem_Cell_line; CVCL_3714
Encyclopedic resources Wikidata; Q54889982
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number26