Cellosaurus LNZTA3WT4 (CVCL_3540)
Cell line name | LNZTA3WT4 | ||||||||||||||||||
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Synonyms | LNZTA3p53WT4; WT4 | ||||||||||||||||||
Accession | CVCL_3540 | ||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: LNZTA3WT4 (RRID:CVCL_3540) | ||||||||||||||||||
Comments | Group: Patented cell line. Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11543. Population: Caucasian. Characteristics: The expression of the luciferase reporter gene as well as the TP53 gene are under the control of a tetO operator. Characteristics: Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16. Microsatellite instability: Stable (MSS) (Sanger). Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11998; TP53. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Omics: CRISPR phenotypic screen. Omics: Deep exome analysis. Omics: Deep quantitative proteome analysis. Omics: DNA methylation analysis. Omics: Transcriptome analysis by microarray. Derived from site: In situ; Brain, right parieto-occipital lobe. | ||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Astrocytoma (NCIt: C60781) Astrocytoma (ORDO: Orphanet_94) | ||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||
Hierarchy | Parent: CVCL_0394 (LN-308) | ||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||
Age at sampling | 60Y | ||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||
STR profile | Source(s): ATCC=CRL-11543; Cosmic-CLP=1240170 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
Publications | Patent=US5807731 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675 PubMed=30971826; DOI=10.1038/s41586-019-1103-9 PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775 | ||||||||||||||||||
Cross-references | |||||||||||||||||||
Cell line collections (Providers) | ATCC; CRL-11543 - Discontinued | ||||||||||||||||||
Cell line databases/resources | CLO; CLO_0007371
cancercelllines; CVCL_3540 Cell_Model_Passport; SIDM01220 Cosmic-CLP; 1240170 DepMap; ACH-002269 LINCS_HMS; 50028 LINCS_LDP; LCL-1345 | ||||||||||||||||||
Biological sample resources | BioSample; SAMN03471340 | ||||||||||||||||||
CRISP screens repositories | BioGRID_ORCS_Cell_line; 931 | ||||||||||||||||||
Chemistry resources | GDSC; 1240170
PharmacoDB; LNZTA3WT4_853_2019 | ||||||||||||||||||
Encyclopedic resources | Wikidata; Q54902866 | ||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-3610
GEO; GSM1670052 | ||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 1995487 | ||||||||||||||||||
Proteomic databases | PRIDE; PXD030304 | ||||||||||||||||||
Sequence databases | EGA; EGAS00001000978 | ||||||||||||||||||
Entry history | |||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||
Last entry update | 10-Sep-2024 | ||||||||||||||||||
Version number | 30 |