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Cellosaurus KON (CVCL_3001)

[Text version]
Cell line name KON
Accession CVCL_3001
Resource Identification Initiative To cite this cell line use: KON (RRID:CVCL_3001)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 32.5 hours (Note=At 28th passage) (DOI=10.5794/jjoms.41.19); 43 hours (Note=Lot 01262007) (JCRB=JCRB0194).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Misspelling: KOS; CGH-DB=369-2.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.36
Native American0.46
East Asian, North79.36
East Asian, South18.6
South Asian0.7
European, North0.27
European, South0.25
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1298215; DepMap=ACH-001542; JCRB=JCRB0194

Markers:
AmelogeninX
CSF1PO11,12
D3S135816
D5S81811,13
D7S8208,11
D8S117910,14
D13S31711,12
D16S5399,11
D18S5114,15
D21S1129,30
FGA22,24
Penta D9
Penta E12,16
TH017,9
TPOX9,11
vWA16,17 (JCRB=JCRB0194)
17 (Cosmic-CLP=1298215; DepMap=ACH-001542)

Run an STR similarity search on this cell line
Publications

DOI=10.5794/jjoms.41.19
Ohara M., Yasui A., Ishikawa T.
Establishment and characterization of a human oral squamous cell carcinoma cell line (KON).
Nihon Koku Geka Gakkai Zasshi 41:19-25(1995)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-i., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0194
Cell line databases/resources CLO; CLO_0009946
cancercelllines; CVCL_3001
CGH-DB; 369-2
Cell_Model_Passport; SIDM00604
Cosmic-CLP; 1298215
DepMap; ACH-001542
LINCS_LDP; LCL-1207
Biological sample resources BioSample; SAMN03471653
CRISP screens repositories BioGRID_ORCS_Cell_line; 913
Chemistry resources GDSC; 1298215
PharmacoDB; KON_778_2019
Encyclopedic resources Wikidata; Q54900289
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827191
GEO; GSM1669999
Polymorphism and mutation databases Cosmic; 1995473
Progenetix; CVCL_3001
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number34