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Cellosaurus KHYG-1 (CVCL_2976)

[Text version]
Cell line name KHYG-1
Synonyms KHYG1; KHYG
Accession CVCL_2976
Resource Identification Initiative To cite this cell line use: KHYG-1 (RRID:CVCL_2976)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Population: Japanese.
Characteristics: IL2 dependent.
Doubling time: 24-48 hours (PubMed=10803526); ~30-40 hours (DSMZ=ACC-725); ~54 hours (Note=Lot 11012010), ~30 hours (Note=Lots 07242006 and 11202015), ~25 hours (Note=Lot 10182016) (JCRB=JCRB0156).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Unspecified (DepMap=ACH-001100).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified (PubMed=10803526; DepMap=ACH-001100).
HLA typing Source: DSMZCellDive=ACC-725
Class I
HLA-AA*11:01:01,24:02:01
HLA-BB*35:01:01,54:01:01
HLA-CC*01:02:01,03:03:01
Class II
HLA-DPDPA1*02:01:01,02:01:01
DPB1*19:01,14:01:01
HLA-DQDQA1*01:03:01,01:03:01
HLA-DRDRA*01:01:01,01:02:02
DRB1*08:03:02,11:01:01
Disease Natural killer cell lymphoblastic leukemia/lymphoma (NCIt: C82217)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 45Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-725; JCRB=JCRB0156

Markers:
AmelogeninX
CSF1PO12
D2S133817,19
D3S135815,16
D5S8189,11
D7S82010,11
D8S117913
D13S3179,13
D16S5399
D18S5113,18
D19S43313,14
D21S1130,32.2
FGA21,24
Penta D11,13
Penta E5
TH016
TPOX9,11
vWA17

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/KHYG-1
Publications

PubMed=10803505; DOI=10.1038/sj.leu.2401778
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma.
Leukemia 14:777-782(2000)

PubMed=10803526; DOI=10.1038/sj.leu.2401769
Yagita M., Huang C.L., Umehara H., Matsuo Y., Tabata R., Miyake M., Konaka Y., Takatsuki K.
A novel natural killer cell line (KHYG-1) from a patient with aggressive natural killer cell leukemia carrying a p53 point mutation.
Leukemia 14:922-930(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x; PMCID=PMC11159954
Liu A., Takakuwa T., Luo W.-J., Fujita S., Aozasa K.
Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection.
Cancer Sci. 97:605-610(2006)

PubMed=19194464; DOI=10.1038/leu.2009.3
Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H., Klinkebiel D.L., Christman J.K., Patel K., Cao K., Shen L., Dybkaer K., Tsui I.F.L., Ali H.H., Shimizu N., Au W.Y., Lam W.L., Chan W.-C.
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Leukemia 23:1139-1151(2009)

PubMed=21052088; DOI=10.1038/leu.2010.255
Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.-Y., Srivastava G., Greiner T.C., Kucuk C., Deffenbacher K.E., Vose J.M., Smith L., Au W.Y., Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.-H., Sng I., Liu X., Loughran T.P. Jr., Armitage J.O., Chan W.-C.
International Peripheral T-cell Lymphoma Project
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro.
Leukemia 25:348-358(2011)

PubMed=25586472; DOI=10.1038/ncomms7025; PMCID=PMC7743911
Kucuk C., Jiang B., Hu X.-Z., Zhang W.-Y., Chan J.K.C., Xiao W.-M., Lack N., Alkan C., Williams J.C., Avery K.N., Kavak P., Scuto A., Sen E., Gaulard P., Staudt L.M., Iqbal J., Zhang W.-W., Cornish A., Gong Q., Yang Q.-P., Sun H., d'Amore F.A., Leppa S., Liu W.-P., Fu K., de Leval L., McKeithan T.W., Chan W.-C.
Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells.
Nat. Commun. 6:6025.1-6025.12(2015)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-725
JCRB; JCRB0156
JCRB; NIHS0226 - Discontinued
Cell line databases/resources cancercelllines; CVCL_2976
Cell_Model_Passport; SIDM01661
DepMap; ACH-001100
DSMZCellDive; ACC-725
Lonza; 733
Encyclopedic resources Wikidata; Q54899912
Experimental variables resources EFO; EFO_0022649
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM472000
Polymorphism and mutation databases Cosmic; 1534877
Cosmic; 1542070
Cosmic; 2025323
Cosmic; 2390214
Cosmic; 2785203
IARC_TP53; 13193
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number28