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Cellosaurus HMC-1-8 (CVCL_2949)

[Text version]
Cell line name HMC-1-8
Synonyms HMC18
Accession CVCL_2949
Resource Identification Initiative To cite this cell line use: HMC-1-8 (RRID:CVCL_2949)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 26 hours (DOI=10.15114/tr.22.27).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous (DepMap=ACH-000721).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Unspecified (DepMap=ACH-000721).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,31:01
HLA-BB*07:13,35:08
HLA-CC*01:02,07:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North83.08
East Asian, South16.92
South Asian0
European, North0
European, South0
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_H204 ! TcHMC-1
Sex of cell Female
Age at sampling 35Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB0166

Markers:
AmelogeninX
CSF1PO7,12
D5S8189,10
D7S82011
D13S3178,10
D16S5399,12
TH017,9
TPOX8,12
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=3488124
Sato T., Sato N., Takahashi S., Koshiba H., Kikuchi K.
Specific cytotoxicity of a long-term cultured T-cell clone on human autologous mammary cancer cells.
Cancer Res. 46:4384-4389(1986)

DOI=10.15114/tr.22.27
Sato T., Sato N., Takahashi S., Okubo M., Yagihashi A., Okazaki A., Okazaki Y., Toda K.
Characterization of two new cancer cell lines derived from human breast tumors.
Tumor Res. 22:27-39(1987)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) JCRB; JCRB0166
JCRB; FDSC0048 - Discontinued
Cell line databases/resources CLO; CLO_0037257
cancercelllines; CVCL_2949
Cell_Model_Passport; SIDM01622
DepMap; ACH-000721
SLKBase; 3552
Biological sample resources BioSample; SAMN03470817
BioSample; SAMN10987868
CRISP screens repositories BioGRID_ORCS_Cell_line; 656
Chemistry resources PharmacoDB; HMC18_552_2019
Encyclopedic resources Wikidata; Q54889908
Experimental variables resources EFO; EFO_0022456
Gene expression databases ArrayExpress; E-MTAB-2770
Polymorphism and mutation databases IARC_TP53; 28374
LiGeA; CCLE_562
Progenetix; CVCL_2949
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number26