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Cellosaurus OV17R (CVCL_2672)

[Text version]
Cell line name OV17R
Synonyms OV-17R
Accession CVCL_2672
Resource Identification Initiative To cite this cell line use: OV17R (RRID:CVCL_2672)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: OCCP ovarian cancer cell line panel.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.39
Native American0
East Asian, North1.99
East Asian, South0
South Asian0
European, North60.17
European, South35.44
Disease Ovarian adenocarcinoma (NCIt: C7700)
Adenocarcinoma of ovary (ORDO: Orphanet_213504)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1480361; DepMap=ACH-001373; ECACC=96020763; PubMed=25230021

Markers:
AmelogeninX
CSF1PO11,14
D2S133824,25
D3S135814,17
D5S81811
D7S8208,10
D8S117913,14
D13S31711,13
D16S5399,13
D18S5113,18
D19S43314,16
D21S1130
FGA21,22
Penta D10,13
Penta E14
TH019 (Cosmic-CLP=1480361; ECACC=96020763)
9,9.3 (DepMap=ACH-001373; PubMed=25230021)
TPOX8,10
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=7707437; DOI=10.1093/jnci/87.7.506
Boocock C.A., Charnock-Jones D.S., Sharkey A.M., McLaren J., Barker P.J., Wright K.A., Twentyman P.R., Smith S.K.
Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma.
J. Natl. Cancer Inst. 87:506-516(1995)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028
Medrano M., Communal L., Brown K.R., Iwanicki M., Normand J., Paterson J., Sircoulomb F., Krzyzanowski P.M., Novak M., Doodnauth S.A., Suarez Saiz F.J., Cullis J., Al-awar R., Neel B.G., McPherson J., Drapkin R.I., Ailles L., Mes-Masson A.-M., Rottapel R.
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Cell Rep. 18:2343-2358(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ECACC; 96020763
Cell line databases/resources cancercelllines; CVCL_2672
Cell_Model_Passport; SIDM00476
Cosmic-CLP; 1480361
DepMap; ACH-001373
Chemistry resources GDSC; 1480361
PharmacoDB; OV17R_1209_2019
Encyclopedic resources Wikidata; Q54936883
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM711699
GEO; GSM1291145
GEO; GSM1670311
GEO; GSM2474981
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number27