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Cellosaurus ONE58 (CVCL_2671)

[Text version]
Cell line name ONE58
Accession CVCL_2671
Resource Identification Initiative To cite this cell line use: ONE58 (RRID:CVCL_2671)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Transformant: ChEBI; CHEBI:46666; Crocidolite asbestos.
Omics: Secretome proteome analysis.
Omics: SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 3373; EP300; Simple; p.Gln1993Ter (c.5797C>T); Zygosity=Heterozygous (DepMap=ACH-001992).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr205Cys (c.614A>G); ClinVar=VCV000376681; Zygosity=Homozygous (DepMap=ACH-001992).
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): CBA=CBA-0143

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133820,23
D3S135817
D5S81812
D7S8207,11
D8S117910,13
D13S3178,12
D16S53912
D18S5111,12
D19S43312
D21S1130,31.2
FGA21
TH018,9
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=1703129; DOI=10.1002/ijc.2910470219
Manning L.S., Whitaker D., Murch A.R., Garlepp M.J., Davis M.R., Musk A.W., Robinson B.W.S.
Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions.
Int. J. Cancer 47:285-290(1991)

PubMed=21642991; DOI=10.1038/ng.855; PMCID=PMC4643098
Bott M.J., Brevet M., Taylor B.S., Shimizu S., Ito T., Wang L., Creaney J., Lake R.A., Zakowski M.F., Reva B., Sander C., Delsite R., Powell S.N., Zhou Q., Shen R.-L., Olshen A.B., Rusch V.W., Ladanyi M.
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Nat. Genet. 43:668-672(2011)

PubMed=25902174; DOI=10.1097/JTO.0000000000000493
Miyanaga A., Masuda M., Tsuta K., Kawasaki K., Nakamura Y., Sakuma T., Asamura H., Gemma A., Yamada T.
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
J. Thorac. Oncol. 10:844-851(2015)

PubMed=28387650; DOI=10.21873/cgp.20023; PMCID=PMC5369310
Creaney J., Dick I.M., Leon J.S., Robinson B.W.S.
A proteomic analysis of the malignant mesothelioma secretome using iTRAQ.
Cancer Genomics Proteomics 14:103-117(2017)

Cross-references
Cell line collections (Providers) CBA; CBA-0143
ECACC; 10092313
Cell line databases/resources cancercelllines; CVCL_2671
DepMap; ACH-001992
Biological sample resources BioSample; SAMN07624412
BioSamples; SAMEA100744
Encyclopedic resources Wikidata; Q54936408
Gene expression databases GEO; GSM726282
Polymorphism and mutation databases Cosmic; 1522773
Cosmic; 1963332
Progenetix; CVCL_2671
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number21