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Cellosaurus U-HO1 (CVCL_2220)

[Text version]
Cell line name U-HO1
Synonyms U-H01; UHO1
Accession CVCL_2220
Resource Identification Initiative To cite this cell line use: U-HO1 (RRID:CVCL_2220)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~4 days (PubMed=18253030); ~100 hours (DSMZ=ACC-626).
Omics: SNP array analysis.
Anecdotal: Andreas Mader, the first author of the paper (PubMed=18253030) describing this cell line is the patient that donated the cell line. As it is not frequent to see a patient 'acknowledged' by being an author this fact should be emphasized.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 9642; PTPN1; Unexplicit; Ex2-8del; Zygosity=Unspecified (CelloPub=CLPUB00457).
  • Gene deletion; HGNC; 11896; TNFAIP3; Zygosity=Heterozygous (PubMed=19380639).
  • Mutation; HGNC; 11896; TNFAIP3; Simple; p.Met43fs (c.127-134del) (del 193-200); Zygosity=Heterozygous (PubMed=19380639).
Disease Hodgkin lymphoma (NCIt: C9357)
Hodgkin lymphoma (ORDO: Orphanet_98293)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UI40 (U-HO1-PTPN1)
Sex of cell Male
Age at sampling 23Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001685; DSMZ=ACC-626

Markers:
AmelogeninX,Y
CSF1PO10
D2S133823,24
D3S135813,17
D5S81811
D7S8208,10
D8S117913,16
D13S31711,12
D16S53911,13
D18S5114
D19S43313,14
D21S1130,32.2
FGA21,24
Penta D9,13
Penta E5,18
TH017,9.3
TPOX8,10
vWA18

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Publications

CLPUB00457
Wegener S., Mader A., Melzner I., Bruderlein S., Moller P.
Lack of PTPN1 (PTP1B) in U-HO1, a new Hodgkin-derived cell line, protects cells from apoptosis.
Haematologica 92 Suppl. 5:39-39(2007)

PubMed=18253030; DOI=10.1159/000112062
Mader A., Bruderlein S., Wegener S., Melzner I., Popov S.W., Muller-Hermelink H.-K., Barth T.F.E., Viardot A., Moller P.
U-HO1, a new cell line derived from a primary refractory classical Hodgkin lymphoma.
Cytogenet. Genome Res. 119:204-210(2007)

PubMed=18820924; DOI=10.1007/s00292-008-1055-6
Moller P., Mader A., Barth T.F.E., Bruderlein S.
U-HO1. A new cell line derived from a primary refractory classical Hodgkin lymphoma.
Pathologe 29 Suppl. 2:317-318(2008)

PubMed=19380639; DOI=10.1084/jem.20090528; PMCID=PMC2715030
Schmitz R., Hansmann M.-L., Bohle V., Martin-Subero J.I., Hartmann S., Mechtersheimer G., Klapper W., Vater I., Giefing M., Gesk S., Stanelle J., Siebert R., Kuppers R.
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
J. Exp. Med. 206:981-989(2009)

PubMed=21144060; DOI=10.1186/1471-2121-11-99; PMCID=PMC3018409
Knecht H., Bruderlein S., Wegener S., Lichtensztejn D., Lichtensztejn Z., Lemieux B., Moller P., Mai S.
3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including 't-stumps'.
BMC Cell Biol. 11:99.1-99.10(2010)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

Cross-references
Cell line collections (Providers) DSMZ; ACC-626
Cell line databases/resources cancercelllines; CVCL_2220
Cell_Model_Passport; SIDM01831
DepMap; ACH-001685
DSMZCellDive; ACC-626
IGRhCellID; U-HO1
Biological sample resources BioSample; SAMN03473507
Encyclopedic resources Wikidata; Q54973621
Gene expression databases GEO; GSM381299
Polymorphism and mutation databases Cosmic; 1289702
Cosmic; 1432042
Progenetix; CVCL_2220
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number29