Cellosaurus NK-92 (CVCL_2142)
Cell line name | NK-92 | ||||||||||||||||||||||||||||||||||||
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Synonyms | NK92; Natural Killer-92; NK-92.05; Neukoplast; aNK | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_2142 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: NK-92 (RRID:CVCL_2142) | ||||||||||||||||||||||||||||||||||||
Comments | Group: Patented cell line. Part of: LL-100 blood cancer cell line panel. Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6670. Population: Caucasian. Characteristics: Laboratory use as a standard cell line for antibody-dependent cell-mediated cytotoxicity (ADCC) testing. Also being developed for cellular adoptive immunotherapy for cancers and viral infections. Characteristics: IL2 dependent. Characteristics: Does not express FCGR3A/CD16. Doubling time: 35.6 +- 6.1 hours (PubMed=31126350); ~40-50 hours (DSMZ=ACC-488). Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV). Omics: Deep exome analysis. Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. Miscellaneous: Neukoplast is used as a trademark to refer to NK-92 cells that are available for non-human research applications while aNK is used as a trademark to refer to cells from the cGMP-grade NK-92 cell-line that is in use for therapeutic human testing. Caution: This cell line is exclusively owned and controlled by NantKwest, Inc. NantKwest and its affiliate, Brink Biologics, Inc. are the sole authorized distributors for both commercial and non-commercial research requestors. There are no other authorized commercial and noncommercial suppliers of NK-92 cells. Contact NantKwest and Brink Biologics for information concerning current inventory and cell line use and support. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: Natural killer cell; CL=CL_0000623. | ||||||||||||||||||||||||||||||||||||
Sequence variations | |||||||||||||||||||||||||||||||||||||
HLA typing | Source: DSMZCellDive=ACC-488
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Disease | Natural killer cell lymphoblastic leukemia/lymphoma (NCIt: C82217) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||||||
Hierarchy | Children:
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Sex of cell | Male | ||||||||||||||||||||||||||||||||||||
Age at sampling | 50Y | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): ATCC=CRL-2407; DSMZ=ACC-488 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/NK-92 https://www.atcc.org/en/support/technical-support/faqs/growth-and-morphology-of-nk-92-cells http://www2.kumc.edu/soalab/LabLinks/cell%20lines/nk92.htm https://brinkbiologics.com/platform/ https://clinicaltrials.gov/ct2/show/NCT00990717 https://clinicaltrials.gov/ct2/show/NCT00900809 https://clinicaltrials.gov/ct2/show/NCT02465957 | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=8152260 PubMed=9118301 PubMed=9573023; DOI=10.1182/blood.V91.10.3850 PubMed=10365666; DOI=10.1089/10430349950018030 PubMed=10803505; DOI=10.1038/sj.leu.2401778 DOI=10.1016/B978-0-12-221970-2.50457-5 PubMed=11454312; DOI=10.1089/152581601750288975 PubMed=12850795; DOI=10.1080/14653240310001523 PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x PubMed=18424763; DOI=10.4049/jimmunol.180.9.6392 PubMed=19194464; DOI=10.1038/leu.2009.3 PubMed=20454443; DOI=10.1155/2010/904767 PubMed=21052088; DOI=10.1038/leu.2010.255 PubMed=21570725; DOI=10.1016/j.molimm.2011.04.010 PubMed=25586472; DOI=10.1038/ncomms7025 PubMed=26559813; DOI=10.1007/s00262-015-1761-x PubMed=30054012; DOI=10.1016/j.molimm.2018.07.015 PubMed=31126350; DOI=10.1186/s40425-019-0612-2 PubMed=31160637; DOI=10.1038/s41598-019-44491-x PubMed=34349345; DOI=10.1007/s10616-021-00476-1 PubMed=36610812; DOI=10.1016/j.jcyt.2022.12.003 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections (Providers) | AddexBio; C0003026/NA - Discontinued
ATCC; CRL-2407 BCRC; 60414 - Discontinued CCTCC; GDC0052 DSMZ; ACC-488 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0008177
CCRID; 4201HUM-CCTCC00052 Cell_Model_Passport; SIDM01143 DSMZCellDive; ACC-488 IPD-IMGT/HLA; 13674 Lonza; 1093 | ||||||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0003287 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03471836 | ||||||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q17149636 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722 GEO; GSM472001 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 1534874
Cosmic; 1542071 Cosmic; 2025326 Cosmic; 2390215 Cosmic; 2785204 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 02-May-2024 | ||||||||||||||||||||||||||||||||||||
Version number | 33 |