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Cellosaurus COLO 849 (CVCL_2002)

[Text version]
Cell line name COLO 849
Synonyms COLO-849; Colo 849; COLO #849; COLO849; Colorado 849
Accession CVCL_2002
Resource Identification Initiative To cite this cell line use: COLO 849 (RRID:CVCL_2002)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: ~50-60 hours (DSMZ=ACC-216).
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Right axillary lymph node; UBERON=UBERON_0001097.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,03:01
HLA-BB*08:01,40:02
HLA-CC*03:04,07:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.07
East Asian, North2.02
East Asian, South0
South Asian0
European, North73.1
European, South24.82
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1137 ! COLO 829
CVCL_1999 ! COLO 829BL
CVCL_L503 ! COLO 831
CVCL_2000 ! COLO 832
CVCL_L504 ! COLO 833
CVCL_L505 ! COLO 834
CVCL_L506 ! COLO 835
CVCL_L507 ! COLO 838
CVCL_2001 ! COLO 839
CVCL_L508 ! COLO 845
CVCL_L509 ! COLO 848
CVCL_2003 ! COLO 853
CVCL_2004 ! COLO 857
CVCL_2005 ! COLO 858
Sex of cell Male
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-216; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D2S133818,26
D3S135816,18
D5S81811
D7S8208,10
D8S117913,14 (PubMed=25877200)
13,16 (DSMZ=ACC-216)
D13S31711,12
D16S53913
D18S5115
D19S43314,15
D21S1127,29
FGA21,25
Penta D9,14
Penta E7,12
TH0110
TPOX8,11
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=8402545; DOI=10.1016/0165-4608(93)90083-X
Morse H.G., Moore G.E.
Cytogenetic homogeneity in eight independent sites in a case of malignant melanoma.
Cancer Genet. Cytogenet. 69:108-112(1993)

PubMed=7780963
Easty D.J., Guthrie B.A., Maung K., Farr C.J., Lindberg R.A., Toso R.J., Herlyn M., Bennett D.C.
Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.
Cancer Res. 55:2528-2532(1995)

PubMed=11668190; DOI=10.1177/002215540104901105
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-216
Cell line databases/resources CLO; CLO_0002578
CLDB; cl872
cancercelllines; CVCL_2002
Cell_Model_Passport; SIDM01870
DepMap; ACH-001045
DSMZCellDive; ACC-216
LINCS_LDP; LCL-1245
Biological sample resources BioSample; SAMN03473234
Chemistry resources PharmacoDB; COLO849_239_2019
Encyclopedic resources Wikidata; Q54814168
Experimental variables resources EFO; EFO_0006379
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM886954
GEO; GSM888022
Polymorphism and mutation databases Cosmic; 888062
IARC_TP53; 21247
Progenetix; CVCL_2002
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number32