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Cellosaurus NALM-16 (CVCL_1834)

[Text version]
Cell line name NALM-16
Synonyms NALM16; Nalm-16
Accession CVCL_1834
Resource Identification Initiative To cite this cell line use: NALM-16 (RRID:CVCL_1834)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 36.7 hours (PubMed=8847894); ~36 hours (DSMZ=ACC-680).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001993; DSMZ=ACC-680

Markers:
AmelogeninX
CSF1PO11
D2S133818
D3S135815,17 (DSMZ=ACC-680)
17 (DepMap=ACH-001993)
D5S81811
D7S82010
D8S117914
D13S31712
D16S53913
D18S5117,18
D19S43313
D21S1129,30 (DSMZ=ACC-680)
30 (DepMap=ACH-001993)
FGA20
Penta D9,12.4 (DSMZ=ACC-680)
9,13 (DepMap=ACH-001993)
Penta E8
TH018
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=155647; PMCID=PMC1457255
Han T., Minowada J.
Use of stimulating capacity of mixed lymphocyte reaction (MLR-S) as a possible marker for the cell-origin of null-cell acute lymphoblastic leukaemia.
Immunology 35:333-339(1978)

PubMed=6928235; DOI=10.1093/jnci/64.3.485
Kohno S.-i., Minowada J., Sandberg A.A.
Chromosome evolution of near-haploid clones in an established human acute lymphoblastic leukemia cell line (NALM-16).
J. Natl. Cancer Inst. 64:485-493(1980)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Nakano A., Harada T., Morikawa S., Kato Y.
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=8847894
Tani A., Tatsumi E., Nakamura F., Kumagai S., Kosaka Y., Sano K., Nakamura H., Amakawa R., Ohno H.
Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.
Leukemia 10:1592-1603(1996)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Matsuo Y., Drexler H.G.
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-680
Cell line databases/resources cancercelllines; CVCL_1834
DepMap; ACH-001993
DSMZCellDive; ACC-680
Biological sample resources BioSample; SAMN03473434
Encyclopedic resources Wikidata; Q54907397
Gene expression databases GEO; GSM5137733
Polymorphism and mutation databases Cosmic; 998707
Cosmic; 999758
Cosmic; 1037712
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number27