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Cellosaurus WERI-Rb-1 (CVCL_1792)

[Text version]
Cell line name WERI-Rb-1
Synonyms WERI-RB-1; WERI-Rb 1; WERI-Rb1; WERI-RB1; WERI Rb-1; WERIRb1; WERI; Wills Eye Research Institute-Retinoblastoma-1
Accession CVCL_1792
Secondary accession CVCL_2757
Resource Identification Initiative To cite this cell line use: WERI-Rb-1 (RRID:CVCL_1792)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Doubling time: 96 hours (PubMed=844036); 50 hours (PubMed=25326674); 84 hours (PubMed=31781967); ~49 hours (DSMZ=ACC-90).
Omics: CTCF ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: Deep quantitative proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Eye, globe; UBERON=UBERON_0010230.
Sequence variations
  • Gene deletion; HGNC; 9884; RB1; Zygosity=Homozygous (PubMed=25326674).
Disease Retinoblastoma (NCIt: C7541)
Retinoblastoma (ORDO: Orphanet_790)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B7IE (WERI-Rb-1 CDDP-R)CVCL_B7ID (WERI-Rb-1 Eto-R)
Sex of cell Female
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-169; DepMap=ACH-001421; DSMZ=ACC-90; JCRB=JCRB3028; RCB=RCB2146; TKG=TKG 0601

Markers:
AmelogeninX
CSF1PO10 (TKG=TKG 0601)
10,12,13 (ATCC=HTB-169; DepMap=ACH-001421; DSMZ=ACC-90; RCB=RCB2146)
11,12 (JCRB=JCRB3028)
D2S133812,15
D3S135814,15
D5S81811,12
D7S82010,12,13 (JCRB=JCRB3028)
10,13 (ATCC=HTB-169; DepMap=ACH-001421; DSMZ=ACC-90; RCB=RCB2146; TKG=TKG 0601)
D8S117912,15
D13S31714
D16S53913
D18S5113,19
D19S43314,15
D21S1129
FGA21
Penta D12,13
Penta E7,11
TH019.3
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/WERI-Rb-1_Stam_protocol.pdf
Publications

PubMed=844036
McFall R.C., Sery T.W., Makadon M.
Characterization of a new continuous cell line derived from a human retinoblastoma.
Cancer Res. 37:1003-1010(1977)

PubMed=679190
McFall R.C., Nagy R.M., Nagle B.T., McGreevy L.M.
Scanning electron microscopic observation of two retinoblastoma cell lines.
Cancer Res. 38:2827-2835(1978)

PubMed=6351622; DOI=10.1016/S0002-9394(14)77822-5
Ohashi Y., Sasabe T., Nishida T., Nishi Y., Higashi H.
Hanganutziu-Deicher heterophile antigen in human retinoblastoma cells.
Am. J. Ophthalmol. 96:321-325(1983)

DOI=10.5795/jjscc.24.451
Tsumuraya M., Nakajima T., Terasaki T., Kodama T., Shimosato Y., Higuchi H., Uei Y.
Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985)

PubMed=2751270
Chan H.S.L., Canton M.D., Gallie B.L.
Chemosensitivity and multidrug resistance to antineoplastic drugs in retinoblastoma cell lines.
Anticancer Res. 9:469-474(1989)

PubMed=1682862; DOI=10.1016/S0161-6420(91)32134-1
Chan H.S.L., Thorner P.S., Haddad G., Gallie B.L.
Multidrug-resistant phenotype in retinoblastoma correlates with P-glycoprotein expression.
Ophthalmology 98:1425-1431(1991)

PubMed=7689221; DOI=10.1073/pnas.90.16.7578; PMCID=PMC47185
Godbout R., Squire J.A.
Amplification of a DEAD box protein gene in retinoblastoma cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:7578-7582(1993)

PubMed=7499444; DOI=10.1007/BF01213319
Inomata M., Saijo N., Kawashima K., Kaneko A., Fujiwara Y., Kunikane H., Tanaka Y.
Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid.
J. Cancer Res. Clin. Oncol. 121:729-738(1995)

PubMed=19686387; DOI=10.1111/j.1471-4159.2009.06322.x; PMCID=PMC3726384
Glubrecht D.D., Kim J.-H., Russell L., Bamforth J.S., Godbout R.
Differential CRX and OTX2 expression in human retina and retinoblastoma.
J. Neurochem. 111:250-263(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23498719; DOI=10.1016/S1470-2045(13)70045-7
Rushlow D.E., Mol B.M., Kennett J.Y., Yee S., Pajovic S., Theriault B.L., Prigoda-Lee N.L., Spencer C., Dimaras H., Corson T.W., Pang R., Massey C., Godbout R., Jiang Z., Zacksenhaus E., Paton K., Moll A.C., Houdayer C., Raizis A., Halliday W., Lam W.L., Boutros P.C., Lohmann D.R., Dorsman J.C., Gallie B.L.
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.
Lancet Oncol. 14:327-334(2013)

PubMed=25326674; DOI=10.1007/s00418-014-1285-z
Busch M.A., Philippeit C., Weise A., Dunker N.
Re-characterization of established human retinoblastoma cell lines.
Histochem. Cell Biol. 143:325-338(2015)

PubMed=27115612; DOI=10.1371/journal.pone.0153323; PMCID=PMC4846005
Kooi I.E., Mol B.M., Massink M.P.G., de Jong M.C., de Graaf P., van der Valk P., Meijers-Heijboer H., Kaspers G.J.L., Moll A.C., te Riele H., Cloos J., Dorsman J.C.
A meta-analysis of retinoblastoma copy numbers refines the list of possible driver genes involved in tumor progression.
PLoS ONE 11:E0153323-E0153323(2016)

PubMed=28713896; DOI=10.3892/ijmm.2017.3058; PMCID=PMC5547939
Liu Y., Fan Z.-G., Li K., Deng F., Xiong Y.-F., Liang M.-X., Ge J.
An optimized gene transfection system in WERI-Rb1 cells.
Int. J. Mol. Med. 40:801-813(2017)

PubMed=29192327; DOI=10.3892/or.2017.6100; PMCID=PMC5783599
Busch M.A., Papior D., Stephan H., Dunker N.
Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines.
Oncol. Rep. 39:160-172(2018)

PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018
Schwermer M., Hiber M., Dreesmann S., Rieb A., Theissen J., Herold T., Schramm A., Temming P., Steenpass L.
Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines.
Exp. Cell Res. 375:92-99(2019)

PubMed=31781967; DOI=10.1007/s00418-019-01832-1
Ravishankar H., Mangani A.S., Shankar M.B., Joshi M., Devasena T., Parameswaran S., Subramaniam K.
Characterization of NCC-RbC-51, an RB cell line isolated from a metastatic site.
Histochem. Cell Biol. 153:101-109(2020)

PubMed=32123578; DOI=10.1038/s41420-020-0237-8; PMCID=PMC7026052
Aubry A., Yu T., Bremner R.
Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy.
Cell Death Discov. 6:2.1-2.12(2020)

PubMed=35409416; DOI=10.3390/ijms23074058; PMCID=PMC9000009
Kakkassery V., Gemoll T., Kraemer M.M., Sauer T., Tura A., Ranjbar M., Grisanti S., Joachim S.C., Mergler S., Reinhard J.
Protein profiling of WERI-RB1 and etoposide-resistant WERI-ETOR reveals new insights into topoisomerase inhibitor resistance in retinoblastoma.
Int. J. Mol. Sci. 23:4058.1-4058.14(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0029002/4899
ATCC; HTB-169
CLS; 300632
DSMZ; ACC-90
ECACC; 06070602
IZSLER; BS TCL 231
JCRB; JCRB3028
JCRB; KURB2683 - Discontinued
RCB; RCB2146
TKG; TKG 0601
Cell line databases/resources CLO; CLO_0009583
CLO; CLO_0009584
CLO; CLO_0051563
CLDB; cl4695
cancercelllines; CVCL_1792
CCRID; 3101HUMTCHu213
Cell_Model_Passport; SIDM01414
DepMap; ACH-001421
DSMZCellDive; ACC-90
IGRhCellID; WERIRb1
Lonza; 1147
Biological sample resources BioSample; SAMN03472730
ENCODE; ENCBS087YAE
ENCODE; ENCBS270AAA
ENCODE; ENCBS282DQM
ENCODE; ENCBS283KOW
ENCODE; ENCBS283WND
ENCODE; ENCBS679NMZ
Encyclopedic resources Wikidata; Q54993776
Experimental variables resources EFO; EFO_0005715
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
GEO; GSM749679
GEO; GSM749766
GEO; GSM749768
GEO; GSM824870
GEO; GSM945263
GEO; GSM945318
GEO; GSM1486290
GEO; GSM2043881
Polymorphism and mutation databases Cosmic; 688119
Cosmic; 909782
Progenetix; CVCL_1792
Proteomic databases PRIDE; PXD030924
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number36