Cellosaurus logo
expasy logo

Cellosaurus SJNB-10 (CVCL_1441)

[Text version]
Cell line name SJNB-10
Synonyms SJ-NB-10; SJ-NB10; SJNB10; NB10; NB10-DH; NB 90-9; NB90-9
Accession CVCL_1441
Resource Identification Initiative To cite this cell line use: SJNB-10 (RRID:CVCL_1441)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; HGNC; 7765; NF1; Unexplicit; Partial deletion; Zygosity=Homozygous (PubMed=20655465).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.93
Native American0
East Asian, North0
East Asian, South0
South Asian1.43
European, North66.44
European, South31.2
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=949171

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811
D7S82011,12
D13S31711
D16S53911,12
TH016
TPOX8,10
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=8490657; DOI=10.1038/ng0193-62
The I., Murthy A.E., Hannigan G.E., Jacoby L.B., Menon A.G., Gusella J.F., Bernards A.
Neurofibromatosis type 1 gene mutations in neuroblastoma.
Nat. Genet. 3:62-66(1993)

PubMed=8516298; DOI=10.1073/pnas.90.12.5539; PMCID=PMC46756
Johnson M.R., Look A.T., DeClue J.E., Valentine M.B., Lowy D.R.
Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.
Proc. Natl. Acad. Sci. U.S.A. 90:5539-5543(1993)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=10935473; DOI=10.1038/sj.neo.7900010; PMCID=PMC1716055
Kong X.-T., Valentine V.A., Rowe S.T., Valentine M.B., Ragsdale S.T., Jones B.G., Wilkinson D.A., Brodeur G.M., Cohn S.L., Look A.T.
Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines.
Neoplasia 1:80-89(1999)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027
Holzel M., Huang S.-D., Koster J., Ora I., Lakeman A., Caron H.N., Nijkamp W., Xie J., Callens T., Asgharzadeh S., Seeger R.C., Messiaen L.M., Versteeg R., Bernards R.
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources CLO; CLO_0037083
cancercelllines; CVCL_1441
Cell_Model_Passport; SIDM00259
Cosmic-CLP; 949171
DepMap; ACH-002278
LINCS_LDP; LCL-1989
Anatomy/cell type resources BTO; BTO:0006052
CRISP screens repositories BioGRID_ORCS_Cell_line; 946
Chemistry resources ChEMBL-Cells; CHEMBL3308172
ChEMBL-Targets; CHEMBL2366243
GDSC; 949171
PharmacoDB; NB10_985_2019
PubChem_Cell_line; CVCL_1441
Encyclopedic resources Wikidata; Q54953554
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM692861
GEO; GSM1670146
Polymorphism and mutation databases Cosmic; 688069
Cosmic; 949171
Cosmic; 1109121
Cosmic; 1518076
Cosmic; 1526644
Cosmic; 1543770
Cosmic; 2239458
IARC_TP53; 27181
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number35