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Cellosaurus LB1047-RCC (CVCL_1364)

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Cell line name LB1047-RCC
Synonyms LB1047RCC; LB1047
Accession CVCL_1364
Resource Identification Initiative To cite this cell line use: LB1047-RCC (RRID:CVCL_1364)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Ludwig Institute for Cancer Research, Brussels Branch; Brussels; Belgium.
Population: Caucasian.
Microsatellite instability: Instable (MSI-high) (Sanger).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
HLA typing Source: PubMed=11369790
Class I
HLA-AA*02:01,24:02:101
HLA-BB*35:01,51
HLA-CC*04:01,16:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.9
Native American0
East Asian, North0.45
East Asian, South0
South Asian20.18
European, North20.14
European, South58.33
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_E908 ! LB1047-EBV
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753577

Markers:
AmelogeninX
CSF1PO11,13
D5S81812,13
D7S8209
D13S31711,12
D16S53911
TH017
TPOX8,10
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=10074909; DOI=10.1002/(SICI)1097-0215(19990315)80:6<799::AID-IJC1>3.0.CO;2-U
Dumas F., Gala J.-L., Berteau P., Brasseur F., Eschwege P., Paradis V., Lacour B., Philippe M., Loric S.
Molecular expression of PSMA mRNA and protein in primary renal tumors.
Int. J. Cancer 80:799-803(1999)

PubMed=11369790; DOI=10.1084/jem.193.10.1189; PMCID=PMC2193327
Probst-Kepper M., Stroobant V., Kridel R., Gaugler B., Landry C., Brasseur F., Cosyns J.-P., Weynand B., Boon T., van den Eynde B.J.
An alternative open reading frame of the human macrophage colony-stimulating factor gene is independently translated and codes for an antigenic peptide of 14 amino acids recognized by tumor-infiltrating CD8 T lymphocytes.
J. Exp. Med. 193:1189-1198(2001)

PubMed=18698046; DOI=10.1158/1078-0432.CCR-08-0028; PMCID=PMC2693478
Tykodi S.S., Fujii N., Vigneron N., Lu S.M., Mito J.K., Miranda M.X., Chou J., Voong L.N., Thompson J.A., Sandmaier B.M., Cresswell P., van den Eynde B.J., Riddell S.R., Warren E.H.
C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients.
Clin. Cancer Res. 14:5260-5269(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28489074; DOI=10.1038/ncomms15165; PMCID=PMC5436135
Sinha R., Winer A.G., Chevinsky M.S., Jakubowski C., Chen Y.-B., Dong Y.-Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J.-D., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165.1-15165.10(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources CLO; CLO_0009979
cancercelllines; CVCL_1364
Cell_Model_Passport; SIDM00187
Cosmic-CLP; 753577
DepMap; ACH-002150
LINCS_LDP; LCL-1765
CRISP screens repositories BioGRID_ORCS_Cell_line; 924
Chemistry resources ChEMBL-Cells; CHEMBL3308329
ChEMBL-Targets; CHEMBL2366136
GDSC; 753577
PharmacoDB; LB1047RCC_820_2019
PubChem_Cell_line; CVCL_1364
Encyclopedic resources Wikidata; Q54902027
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670033
Polymorphism and mutation databases Cosmic; 753577
IARC_TP53; 21460
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number36