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Cellosaurus HuO-3N1 (CVCL_1297)

[Text version]
Cell line name HuO-3N1
Synonyms HuO3N1; HUO3N1
Accession CVCL_1297
Resource Identification Initiative To cite this cell line use: HuO-3N1 (RRID:CVCL_1297)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Characteristics: Established from a xenograft established in a nude mice.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala76fs*73 (c.225_226insT); Zygosity=Heterozygous (Cosmic-CLP=909977; DepMap=ACH-002142).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.58
Native American0
East Asian, North72.02
East Asian, South23.28
South Asian1.73
European, North1.15
European, South0.24
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=909977; JCRB=JCRB0413; RCB=RCB2104; TKG=TKG 0452

Markers:
AmelogeninX
CSF1PO10
D5S81810,12
D7S82011,12
D13S3179,10
D16S53912
TH017
TPOX8
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=3862491; DOI=10.1097/00003086-198510000-00038
Yamane T.
Establishment and characterization of cell lines derived from a human osteosarcoma.
Clin. Orthop. Relat. Res. 199:261-271(1985)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0413
RCB; RCB2104
TKG; TKG 0452
Cell line databases/resources CLO; CLO_0050099
cancercelllines; CVCL_1297
Cell_Model_Passport; SIDM00584
Cosmic-CLP; 909977
DepMap; ACH-002142
LINCS_LDP; LCL-1422
Anatomy/cell type resources BTO; BTO:0002431
Biological sample resources BioSample; SAMN03471625
Chemistry resources ChEMBL-Cells; CHEMBL3308818
ChEMBL-Targets; CHEMBL1075475
GDSC; 909977
PharmacoDB; HuO3N1_642_2019
PubChem_Cell_line; CVCL_1297
Encyclopedic resources Wikidata; Q54896886
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM320824
GEO; GSM1669920
Polymorphism and mutation databases Cosmic; 909977
IARC_TP53; 21389
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number36