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Cellosaurus D458 Med (CVCL_1161)

[Text version]
Cell line name D458 Med
Synonyms D-458 Med; D-458MED; D458MED; D458Med; Med 458; D-458; D458
Accession CVCL_1161
Resource Identification Initiative To cite this cell line use: D458 Med (RRID:CVCL_1161)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 3.45 days (PubMed=1904513).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Cerebrospinal fluid; UBERON=UBERON_0001359.
Sequence variations
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=22343310).
Disease Medulloblastoma, non-WNT/non-SHH, group 3 (NCIt: C129445)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1275 ! D425 Med
Sex of cell Male
Age at sampling 6-7Y
Category Cancer cell line
Publications

PubMed=1822845
Wikstrand C.J., Friedman H.S., Bigner D.D.
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

PubMed=1904513
He X.-M., Wikstrand C.J., Friedman H.S., Bigner S.H., Pleasure S.J., Trojanowski J.Q., Bigner D.D.
Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.
Lab. Invest. 64:833-843(1991)

PubMed=9283596; DOI=10.1016/S0165-4608(96)00404-9
Bigner S.H., McLendon R.E., Fuchs H.E., McKeever P.E., Friedman H.S.
Chromosomal characteristics of childhood brain tumors.
Cancer Genet. Cytogenet. 97:125-134(1997)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20847082; DOI=10.1093/neuonc/noq091; PMCID=PMC3018940
Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y.-F., Marquez V.E., Cho Y.-J., Pomeroy S.L.
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=22343310; DOI=10.1016/j.neulet.2012.02.022
Ghassemifar S., Mendrysa S.M.
MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.
Neurosci. Lett. 513:106-110(2012)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281; PMCID=PMC4198154
Bandopadhayay P., Bergthold G., Nguyen B., Schubert S., Gholamin S., Tang Y.-J., Bolin S., Schumacher S.E., Zeid R., Masoud S., Yu F.-R., Vue N., Gibson W.J., Paolella B.R., Mitra S.S., Cheshier S.H., Qi J., Liu K.-W., Wechsler-Reya R.J., Weiss W.A., Swartling F.J., Kieran M.W., Bradner J.E., Beroukhim R., Cho Y.-J.
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin. Cancer Res. 20:912-925(2014)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004; PMCID=PMC5079239
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1161
Cell_Model_Passport; SIDM01493
DepMap; ACH-001054
CRISP screens repositories BioGRID_ORCS_Cell_line; 1664
Encyclopedic resources Wikidata; Q54817230
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM919360
GEO; GSM1234976
GEO; GSM1234977
Polymorphism and mutation databases Cosmic; 946381
IARC_TP53; 27691
Progenetix; CVCL_1161
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number24