Cellosaurus logo
expasy logo

Cellosaurus CHP-134 (CVCL_1124)

[Text version]
Cell line name CHP-134
Synonyms CHP 134; CHP_134; CHP134; Children's Hospital of Philadelphia-134
Accession CVCL_1124
Resource Identification Initiative To cite this cell line use: CHP-134 (RRID:CVCL_1124)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 57.6 hours (PubMed=10079); ~30 hours (DSMZ=ACC-653).
Karyotypic information: Pseudodiploid (PubMed=71759).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Adrenal gland; UBERON=UBERON_0002369.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.04
Native American0
East Asian, North0.15
East Asian, South0
South Asian0.93
European, North70.26
European, South28.62
Disease Adrenal gland neuroblastoma (NCIt: C4827)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 1Y1M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910941; DepMap=ACH-001338; DSMZ=ACC-653; ECACC=06122002; RCB=RCB0487

Markers:
AmelogeninX,Y
CSF1PO9,12 (Cosmic-CLP=910941; RCB=RCB0487)
9,13 (DepMap=ACH-001338; DSMZ=ACC-653; ECACC=06122002)
D2S133820,27
D3S135816
D5S81811,12
D7S8209
D8S11798,14 (DepMap=ACH-001338)
14 (DSMZ=ACC-653)
D13S3178,10,11 (DepMap=ACH-001338)
8,11 (Cosmic-CLP=910941; DSMZ=ACC-653; ECACC=06122002; RCB=RCB0487)
D16S53911 (RCB=RCB0487)
11,13 (Cosmic-CLP=910941; DepMap=ACH-001338; DSMZ=ACC-653; ECACC=06122002)
D18S5115,18
D19S43312,13
D21S1128,29
FGA21,25
Penta D9
Penta E5,7
TH019,9.3
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=10079
Schlesinger H.R., Gerson J.M., Moorhead P.S., Maguire H., Hummeler K.
Establishment and characterization of human neuroblastoma cell lines.
Cancer Res. 36:3094-3100(1976)

PubMed=71759; DOI=10.1126/science.71759
Balaban-Malenbaum G.B., Gilbert F.
Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line.
Science 198:739-741(1977)

PubMed=6113887
Schlesinger H.R., Rorke-Adams L.B., Jamieson R., Hummeler K.
Neuronal properties of neuroectodermal tumors in vitro.
Cancer Res. 41:2573-2575(1981)

PubMed=7139592; DOI=10.1016/0165-4608(82)90105-4
Gilbert F., Balaban-Malenbaum G.B., Moorhead P.S., Bianchi D., Schlesinger H.R.
Abnormalities of chromosome 1p in human neuroblastoma tumors and cell lines.
Cancer Genet. Cytogenet. 7:33-42(1982)

DOI=10.1016/B978-0-12-008304-6.50015-4
Biedler J.L., Meyers M.B., Spengler B.A.
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff S., Hertz L. (eds.); pp.267-307; Academic Press; New York; USA (1983)

PubMed=6888561; DOI=10.1038/305245a0
Schwab M., Alitalo K., Klempnauer K.-H., Varmus H.E., Bishop J.M., Gilbert F., Brodeur G.M., Goldstein M.N., Trent J.M.
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 305:245-248(1983)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=12702577
Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J.
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=15892104; DOI=10.1002/gcc.20198
Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K.A., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=18923524; DOI=10.1038/nature07399
Chen Y.-Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L.-L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S.
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X.-Y., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-653
ECACC; 06122002
RCB; RCB0487
Cell line databases/resources CLO; CLO_0051417
cancercelllines; CVCL_1124
Cell_Model_Passport; SIDM00285
CGH-DB; 75-1
CGH-DB; 9099-4
Cosmic-CLP; 910941
DepMap; ACH-001338
DSMZCellDive; ACC-653
Anatomy/cell type resources BTO; BTO:0002989
Biological sample resources BioSample; SAMN03472330
BioSample; SAMN03473466
Chemistry resources ChEMBL-Cells; CHEMBL3308253
ChEMBL-Targets; CHEMBL2366128
GDSC; 910941
PharmacoDB; CHP134_199_2019
PubChem_Cell_line; CVCL_1124
Encyclopedic resources Wikidata; Q54813265
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM313800
GEO; GSM333795
GEO; GSM563356
GEO; GSM692863
GEO; GSM1366404
GEO; GSM1669677
GEO; GSM2371222
GEO; GSM2394376
GEO; GSM3145699
Polymorphism and mutation databases Cosmic; 688063
Cosmic; 801744
Cosmic; 848934
Cosmic; 910941
Cosmic; 920253
Cosmic; 930063
Cosmic; 947707
Cosmic; 1019934
Cosmic; 1037353
Cosmic; 1099150
Cosmic; 1109362
Cosmic; 1153779
Cosmic; 1161986
Cosmic; 1526620
Cosmic; 2131592
Cosmic; 2393629
Cosmic; 2485943
IARC_TP53; 21226
Progenetix; CVCL_1124
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number38