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Cellosaurus BB49-HNC (CVCL_1077)

[Text version]
Cell line name BB49-HNC
Synonyms BB49 HNC; BB49HNC; BB49-SCCHN
Accession CVCL_1077
Resource Identification Initiative To cite this cell line use: BB49-HNC (RRID:CVCL_1077)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Ludwig Institute for Cancer Research, Brussels Branch; Brussels; Belgium.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.66
Native American0.55
East Asian, North0.98
East Asian, South0
South Asian2.14
European, North57.6
European, South38.06
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_VU51 ! BB49-EBV
Sex of cell Female
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753532

Markers:
AmelogeninX
CSF1PO12,13
D5S81812
D7S8209,12
D13S3178,11
D16S53912
TH016
TPOX7,9
vWA15,19

Run an STR similarity search on this cell line
Publications

PubMed=9271594; DOI=10.1084/jem.186.5.785; PMCID=PMC2199018
Mandruzzato S., Brasseur F., Andry G., Boon T., van der Bruggen P.
A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.
J. Exp. Med. 186:785-793(1997)

PubMed=11751535; DOI=10.1093/clinchem/48.1.25
Zammatteo N., Lockman L., Brasseur F., De Plaen E., Lurquin C., Lobert P.-E., Hamels S., Boon T., Remacle J.
DNA microarray to monitor the expression of MAGE-A genes.
Clin. Chem. 48:25-34(2002)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CLO; CLO_0009940
cancercelllines; CVCL_1077
Cell_Model_Passport; SIDM00174
Cosmic-CLP; 753532
DepMap; ACH-002213
LINCS_LDP; LCL-1574
Chemistry resources ChEMBL-Cells; CHEMBL3308282
ChEMBL-Targets; CHEMBL2366295
GDSC; 753532
PharmacoDB; BB49HNC_75_2019
PubChem_Cell_line; CVCL_1077
Encyclopedic resources Wikidata; Q54795063
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669608
Polymorphism and mutation databases Cosmic; 753532
Cosmic; 2116768
IARC_TP53; 21187
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number31